Rho GTPases are well known for their roles in regulating cell migration, and also contribute
to a variety of other cellular responses. They are subdivided into 2 groups: typical and …

Neuroblastoma is a neural crest derived malignancy of the peripheral nervous system and is
the most common and deadliest tumor of infancy. It is characterized by clinical heterogeneity …

The Hanahan and Weinberg “hallmarks of cancer” papers provide a useful structure for
considering the various mechanisms driving cancer progression, and the same might be …

In vitro and in vivo studies and evidence from human tumors have long implicated Rho
GTPase signaling in the formation and dissemination of a range of cancers. Recently next …

Directly targeting oncogenic V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (K-Ras)
with small-molecule inhibitors has historically been considered prohibitively challenging …

Variants in RAC3, encoding a small GTPase RAC3 which is critical for the regulation of actin
cytoskeleton and intracellular signal transduction, are associated with a rare …

Rho GTPases are involved in the acquisition of all the hallmarks of cancer, which comprise 6
biological capabilities acquired during the development of human tumors. The hallmarks …

RAC1 P29 is the third most commonly mutated codon in human cutaneous melanoma, after
BRAF V600 and NRAS Q61. Here, we study the role of RAC1 P29S in melanoma …

This article focuses on the role of Rho family GTPases, particularly Rac1 and Rac1b in TGF‐
β‐induced epithelial‐mesenchymal transition (EMT) and EMT‐associated responses such …

The mechanotransduction is the process by which cells sense mechanical stimuli such as
elasticity, viscosity, and nanotopography of extracellular matrix and translate them into …