Found in all organisms, pyruvate dehydrogenase complexes (PDC) are the keystones of
prokaryotic and eukaryotic energy metabolism. In eukaryotic organisms these multi …

Chronic exposure to high glucose inside the human body helps in the progression of cancer
by activating various signaling pathways including PI3K, Akt, mTOR, Ras, Raf, MAPK, and …

Diabetes, a chronic metabolic disorder disrupting blood sugar regulation, has emerged as a
prominent silent pandemic. Uncontrolled diabetes predisposes an individual to develop fatal …

Metabolic pathways drive cellular behavior. Severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) infection causes lung tissue damage directly by targeting cells or indirectly …

Respiratory syncytial virus (RSV) is a significant cause of acute lower respiratory tract
infections, particularly in vulnerable populations such as neonates, infants, young children …

Sepsis is identified as a potentially lethal organ impairment triggered by an inadequate host
reaction to infection (Sepsis-3). Viral sepsis is a potentially deadly organ impairment state …

Influenza represents a major and ongoing public health hazard. Current collaborative efforts
are aimed toward creating a universal flu vaccine with the goals of both improving …

Viruses are obligatory protein-coated units and often utilize the metabolic functions of the
cells they infect. Viruses hijack cellular metabolic functions and cause consequences that …

Development of acute respiratory distress syndrome (ARDS) in influenza A virus (IAV)-
infected mice is associated with inhibition of ATII (alveolar type II) epithelial cell de novo …

High-altitude pulmonary edema (HAPE) is a life-threatening altitude sickness afflicting
certain individuals after rapid ascent to high altitude above 2500 m. In the setting of HAPE …