The function of neural circuits and networks can be controlled, in part, by modulating the
synchrony of their components' activities. Network hypersynchrony and altered oscillatory …

Alzheimer's disease is the most frequent neurodegenerative disorder and the most common
cause of dementia in the elderly. Diverse lines of evidence suggest that amyloid-β (Aβ) …

Alzheimer's disease (AD) results in cognitive decline and altered network activity, but the
mechanisms are unknown. We studied human amyloid precursor protein (hAPP) transgenic …

Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) and tau deposition in brain. It
has emerged that Aβ toxicity is tau dependent, although mechanistically this link remains …

Alzheimer's disease (AD), the most common neurodegenerative disorder, is a growing
public health problem and still lacks effective treatments. Recent evidence suggests that …

Transgenic mouse models have been used extensively to model the cognitive impairments
arising from Alzheimer's disease (AD)-related pathology. However, less is known about the …

Traditionally, the impairment of cognitive functions in Alzheimeŕs disease (AD) is thought to
result from a reduction in neuronal and synaptic activities, and ultimately cell death. Here …

Seizures in the human temporal lobe transiently impair cognition and steadily damage
hippocampal circuitry, leading to progressive memory loss. Similarly, the toxic accumulation …

Temporal lobe epilepsy represents a major cause of drug-resistant epilepsy. Cognitive
impairment is a frequent comorbidity, but the mechanisms are not fully elucidated. We …

Alzheimer's disease (AD) is the most frequent neurodegenerative disorder that commonly
causes dementia in the elderly. Recent evidence indicates that network abnormalities …