Preeclampsia (PE) is a leading cause for peripartal morbidity, especially if developing early
in gestation. To enable prophylaxis in the prevention of PE, pregnancies at risk of PE must …

The lack of a precise stratification algorithm for predicting patients at high risk of graft
rejection challenges the current solid organ transplantation (SOT) clinical setting. In fact, the …

Epigenetic memory, which refers to the ability of cells to retain and transmit epigenetic marks
to their daughter cells, maintains unique gene expression patterns. Establishing …

An extreme chronic wound tissue microenvironment causes epigenetic gene silencing. An
unbiased whole-genome methylome was studied in the wound-edge tissue of patients with …

Epigenetic mechanisms, such as DNA methylation, affect tubular maladaptive response after
Acute Kidney Injury (AKI) and accelerate renal aging. Upon ischemia/reperfusion (I/R) injury …

There is a need to define regions of gene activation or repression that control human kidney
cells in states of health, injury, and repair to understand the molecular pathogenesis of …

Clinical application of biomarkers is an integral component of transplant care. Clinicians and
scientists alike are in search of better biomarkers than the current serologic (serum …

Donor organs are exposed to sequential temperature changes during the transplantation
process. The role of donor warm ischemia and cold ischemia times on post-transplant …

Acute kidney injury (AKI) is a common finding in kidney donors and recipients. AKI in kidney
donor, which increases the risk of delayed graft function (DGF), may not by itself jeopardize …

Although decades of the reductionist approach achieved great milestones in optimizing the
immunosuppression therapy, traditional clinical parameters still fail in predicting both acute …