Cell-free DNA methylome analysis for early preeclampsia prediction

M De Borre, H Che, Q Yu, L Lannoo, K De Ridder… - Nature Medicine, 2023 - nature.com
Preeclampsia (PE) is a leading cause for peripartal morbidity, especially if developing early
in gestation. To enable prophylaxis in the prevention of PE, pregnancies at risk of PE must …

Clinical epigenetics and acute/chronic rejection in solid organ transplantation: an update

M Vasco, G Benincasa, C Fiorito, M Faenza… - Transplantation …, 2021 - Elsevier
The lack of a precise stratification algorithm for predicting patients at high risk of graft
rejection challenges the current solid organ transplantation (SOT) clinical setting. In fact, the …

Epigenetic memory contributing to the pathogenesis of AKI-to-CKD transition

F Tanemoto, M Nangaku, I Mimura - Frontiers in Molecular …, 2022 - frontiersin.org
Epigenetic memory, which refers to the ability of cells to retain and transmit epigenetic marks
to their daughter cells, maintains unique gene expression patterns. Establishing …

Genome-wide DNA hypermethylation opposes healing in patients with chronic wounds by impairing epithelial-mesenchymal transition

K Singh, Y Rustagi, AS Abouhashem… - The Journal of …, 2022 - Am Soc Clin Investig
An extreme chronic wound tissue microenvironment causes epigenetic gene silencing. An
unbiased whole-genome methylome was studied in the wound-edge tissue of patients with …

[HTML][HTML] Complement component C5a induces aberrant epigenetic modifications in renal tubular epithelial cells accelerating senescence by Wnt4/βcatenin signaling …

G Castellano, R Franzin, F Sallustio, A Stasi… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Epigenetic mechanisms, such as DNA methylation, affect tubular maladaptive response after
Acute Kidney Injury (AKI) and accelerate renal aging. Upon ischemia/reperfusion (I/R) injury …

The chromatin landscape of healthy and injured cell types in the human kidney

DL Gisch, M Brennan, BB Lake, J Basta… - Nature …, 2024 - nature.com
There is a need to define regions of gene activation or repression that control human kidney
cells in states of health, injury, and repair to understand the molecular pathogenesis of …

[HTML][HTML] Role of novel biomarkers in kidney transplantation

KJ Swanson, F Aziz, N Garg, M Mohamed… - World journal of …, 2020 - ncbi.nlm.nih.gov
Clinical application of biomarkers is an integral component of transplant care. Clinicians and
scientists alike are in search of better biomarkers than the current serologic (serum …

[HTML][HTML] “Time is tissue”—A minireview on the importance of donor nephrectomy, donor hepatectomy, and implantation times in kidney and liver transplantation

L Heylen, J Pirenne, M Naesens, B Sprangers… - American Journal of …, 2021 - Elsevier
Donor organs are exposed to sequential temperature changes during the transplantation
process. The role of donor warm ischemia and cold ischemia times on post-transplant …

Acute kidney injury (AKI) before and after kidney transplantation: causes, medical approach, and implications for the long-term outcomes

A Palmisano, I Gandolfini, M Delsante… - Journal of Clinical …, 2021 - mdpi.com
Acute kidney injury (AKI) is a common finding in kidney donors and recipients. AKI in kidney
donor, which increases the risk of delayed graft function (DGF), may not by itself jeopardize …

“Transplantomics” for predicting allograft rejection: real-life applications and new strategies from Network Medicine

G Benincasa, M Viglietti, E Coscioni, C Napoli - Human Immunology, 2023 - Elsevier
Although decades of the reductionist approach achieved great milestones in optimizing the
immunosuppression therapy, traditional clinical parameters still fail in predicting both acute …