The lymphatic vasculature, which accompanies the blood vasculature in most organs, is
indispensable in the maintenance of tissue fluid homeostasis, immune cell trafficking, and …

Heart failure is a devastating condition, the progression of which culminates in a mismatch of
oxygen supply and demand, with limited options for treatment. Heart failure has several …

Lymphatic vessels drain excess tissue fluids to maintain the interstitial environment.
Lymphatic capillaries develop during the progression of tissue fibrosis in various clinical and …

The heart is imbued with a vast lymphatic network that is responsible for fluid homeostasis
and immune cell trafficking. Disturbances in the forces that regulate microvascular fluid …

Mechanisms of the transition from compensatory hypertrophy to heart failure are poorly
understood and the roles of vascular endothelial growth factors (VEGFs) in this process …

Background Heart failure (HF) is a growing public health burden, with high prevalence and
mortality rates. A proportion of patients with HF have a normal ventricular ejection fraction …

The mammalian circulatory system comprises both the cardiovascular system and the
lymphatic system. In contrast to the closed, high-pressure and circular blood vascular …

Experimental studies showed that 17β-estradiol (E2) and activated Estrogen Receptors (ER)
protect the heart from ischemic injury. However, the underlying molecular mechanisms are …

Lymphatic endothelial cell homeostasis plays important roles in normal physiological
cardiac functions, and its dysfunction significantly influences pathological cardiac …

Heart failure (HF) is a growing public health burden, with high prevalence and mortality
rates. In contrast to ischemic heart failure (IHF), the diagnosis of non-ischemic heart failure …