Deformability is an essential feature of blood cells (RBCs) that enables them to travel
through even the smallest capillaries of the human body. Deformability is a function of (i) …

Red Blood Cells (RBCs) need to deform and squeeze through narrow capillaries.
Decreased deformability of RBCs is, therefore, one of the factors that can contribute to the …

Sickle cell disease (SCD) is a genetic disease caused by a single mutation in the β-globin
gene, leading to the production of an abnormal hemoglobin called hemoglobin S (HbS) …

Erythrocytes regulate vascular function through the modulation of oxygen delivery and the
scavenging and generation of nitric oxide (NO). First, hemoglobin inside the red blood cell …

Studies performed in the last decades have highlighted the need to better understand the
contribution of the endothelium, vascular function, oxidative stress, inflammation …

Sickle cell disease and β-thalassaemia are inherited haemoglobinopathies resulting in
structural and quantitative changes in the β-globin chain. These changes lead to instability …

Mid-life stage adults are at higher risk of developing venous thrombosis
(VT)/thromboembolism (VT/E). Aging is characterized by an overproduction of reactive …

Sickle cell disease (SCD) is an inherited monogenic disorder and the most common severe
hemoglobinopathy in the world. SCD is characterized by a point mutation in the β-globin …

The main function of red blood cells (RBCs) is the transport of respiratory gases along the
vascular tree. To fulfill their task, RBCs are able to elastically deform in response to …

Anemia is a common complication of chronic kidney disease, affecting the quality of life of
patients. Among various factors, such as iron and erythropoietin deficiency, reduced red …