Pseudomonas aeruginosa: a clinical and genomics update

AC Pelegrin, M Palmieri, C Mirande… - FEMS Microbiology …, 2021 - academic.oup.com
Antimicrobial resistance (AMR) has become a global medical priority that needs urgent
resolution. Pseudomonas aeruginosa is a versatile, adaptable bacterial species with …

Dramatic increase in antimicrobial resistance in ESKAPE clinical isolates over the 2010-2020 decade in India

AS Kharat, N Makwana, M Nasser, S Gayen… - International Journal of …, 2024 - Elsevier
ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella
pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter …

Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis

T Mehrotra, D Konar, AK Pragasam… - Proceedings of the …, 2023 - National Acad Sciences
Microbes evolve rapidly by modifying their genomes through mutations or through the
horizontal acquisition of mobile genetic elements (MGEs) linked with fitness traits such as …

Nucleotide substitutions in the mexR, nalC and nalD regulator genes of the MexAB-OprM efflux pump are maintained in Pseudomonas aeruginosa genetic …

P Aguilar-Rodea, G Zúñiga, R Cerritos… - PLoS …, 2022 - journals.plos.org
Pseudomonas aeruginosa has different resistant mechanisms including the constitutive
MexAB-OprM efflux pump. Single nucleotide polymorphisms (SNPs) in the mexR, nalC, and …

Resistance to ceftazidime–avibactam and other new β-lactams in Pseudomonas aeruginosa clinical isolates: a multi-center surveillance study

F Valzano, G La Bella, T Lopizzo, A Curci… - Microbiology …, 2024 - journals.asm.org
New β-lactam–β-lactamase inhibitor combinations represent last-resort antibiotics to treat
infections caused by multidrug-resistant Pseudomonas aeruginosa. Carbapenemase gene …

Successful use of Cefepime-Zidebactam (WCK 5222) as a salvage therapy for the treatment of disseminated extensively drug-resistant New Delhi Metallo-β …

PK Tirlangi, BS Wanve, RR Dubbudu… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
With limited and often toxic treatment options, carbapenem-resistant Gram-negative
infections are associated with significant mortality. Cefepime-zidebactam is a promising …

New Variants of Pseudomonas aeruginosa High-Risk Clone ST233 Associated with an Outbreak in a Mexican Paediatric Hospital

P Aguilar-Rodea, EL Estrada-Javier, V Jiménez-Rojas… - Microorganisms, 2022 - mdpi.com
Recent multidrug resistance in Pseudomonas aeruginosa has favoured the adaptation and
dissemination of worldwide high-risk strains. In June 2018, 15 P. aeruginosa strains isolated …

Molecular genetic analysis of an XDR Pseudomonas aeruginosa ST664 clone carrying multiple conjugal plasmids

Z Li, Z Cai, Z Cai, Y Zhang, T Fu, Y Jin… - Journal of …, 2020 - academic.oup.com
Objectives A group of ST664 XDR Pseudomonas aeruginosa strains have been isolated
from a burn clinic. Here we decipher their resistomes and likely mechanisms of resistance …

Diversity of carbapenem resistance mechanisms in clinical gram-negative bacteria in Pakistan

L Hadjadj, MA Syed, SA Abbasi, JM Rolain… - Microbial Drug …, 2021 - liebertpub.com
Antibiotic resistance is a health challenge worldwide. Carbapenem resistance in Gram-
negative bacteria is a major problem since treatment options are very limited. Tigecycline …

Carbapenem and colistin-resistant bacteria in North Lebanon: Coexistence of mcr-1 and NDM-4 genes in Escherichia coli

C Al-Bayssari, TN Dagher, S El Hamoui… - The Journal of Infection …, 2021 - jidc.org
Introduction: The increasing incidence of infections caused by multidrug-resistant bacteria is
considered a global health problem. This study aimed to investigate this resistance in Gram …