Liver cancer is the second most lethal cancer in the world with limited treatment options.
Hepatocellular carcinoma (HCC), which accounts for more than 80% of all liver cancers, has …

Liver failure induced by systemic inflammatory response (SIRS) is often associated with
mitochondrial dysfunction but the mechanism linking SIRS and mitochondria-mediated liver …

GH is an important regulator of body growth and composition as well as numerous other
metabolic processes. In particular, liver plays a key role in the GH/IGF-I axis, because the …

The liver is essential for survival due to its critical role in the regulation of metabolic
homeostasis. Metabolism of xenobiotics, such as environmental chemicals and drugs by the …

Non-pituitary growth hormone (npGH) expression is well established in extrapituitary
tissues, but an understanding of the physiological role of npGH remains rather limited. Pro …

Liver fibrosis, or cirrhosis, is a common end-stage condition of many chronic liver diseases
after incomplete recovery from hepatocyte damage. During fibrosis progression …

The rising prevalence of obesity came along with an increase in associated metabolic
disorders in Western countries. Non-alcoholic fatty liver disease (NAFLD) represents the …

Hepatocellular carcinoma (HCC) can be the last step of nonalcoholic fatty liver disease
(NAFLD) evolution, and the main characteristic of NAFLD is alteration in lipid metabolism …

Autosomal dominant polycystic kidney disease (ADPKD) leads to renal failure. The hallmark
of ADPKD is increased epithelial proliferation, which has been proposed to be due to …

Results Compared with cirrhotic patients without HCC and healthy controls, cirrhotic patients
with HCC had significantly lower hepatic expression of GHR, STAT5, and IGF-1proteins …