Normal and diseased cells release bilayered membrane-bound nanovesicles into interstitial
spaces and into bodily fluids. A subgroup of such microvesicles is called exosomes and is …

Present therapeutic approaches do not effectively target metastatic cancers, often limited by
their inability to eliminate already-seeded non-proliferative, growth-arrested, or therapy …

Vascular mimicry is induced by a wide array of genes with functions related to cancer
stemness, hypoxia, angiogenesis and autophagy. Vascular mimicry competent (VM …

Brain metastasis (BM) predominantly occurs in triple-negative (TN) and epidermal growth
factor 2 (HER2)-positive breast cancer (BC) patients, and currently, there is an unmet need …

The molecular mechanisms and genetic programs required for cancer metastasis are
sometimes overlapping, but components are clearly distinct from those promoting growth of …

Molecular and non‐invasive imaging are rapidly emerging fields in preclinical cancer drug
discovery. This is driven by the need to develop more efficacious and safer treatments, the …

Genetically engineered mouse models of pancreatic cancer that recapitulate human
pancreatic tumorigenesis have been established. However, the cost associated with …

The hypothalamic-based kisspeptin-signaling system is a major positive regulator of the
neuroendocrine-reproductive axis in mammals. During the last decade, major advances …

We present a cancer nanomedicine based on acidic pH targeted gold nanorods designed
for multispectral optoacoustic tomography (MSOT). We have designed gold nanorods …

Background: pH-low insertion peptides (pHLIP) can serve as a targeting moiety that enables
pH-sensitive probes to detect solid tumors. Using these probes in conjunction with …