Bone morphogenetic proteins (BMPs) are secreted cytokines that were initially discovered
on the basis of their ability to induce bone. Several decades of research have now …

Germline development in vivo is dependent on the environment formed by somatic cells and
the differentiation cues they provide; hence, the impact of local factors is highly relevant to …

Emerging studies indicate that the Hippo pathway, a highly conserved pathway that
regulates organ size control, plays an important role in governing ovarian physiology …

Recent studies show that pre-follicular mouse oogenesis takes place in germline cysts,
highly conserved groups of oogonial cells connected by intercellular bridges that develop as …

Aging animals display a broad range of progressive degenerative changes, and one of the
most fascinating is the decline of female reproductive function. In the model organism …

The immune privilege of the testes is necessary to prevent immune attacks to gamete-
specific antigens and paternal major histocompatibility complex (MHC) antigens, allowing …

Decidualization is an intricate biological process where extensive morphological, functional,
and genetic changes take place in endometrial stromal cells to support the development of …

Infertility is one of the most common non-communicable diseases, affecting both men and
women equally. Ovarian reserve, the number of primordial follicles in the ovaries is believed …

The follicle is the functional unit of the ovary, whereby ovarian development is largely
dependent on the development of the follicles themselves. The activation, growth, and …

During early pregnancy in the mouse, nidatory estrogen (E2) stimulates endometrial
receptivity by activating a network of signaling pathways that is not yet fully characterized …