Aim: Prospective studies support the clinical impact of pharmacogenomics (PGx)-guided
prescribing to reduce severe and potentially fatal adverse effects. Drug-gene interactions …

Gene variants in the UGT1A1 gene are strongly associated with circulating bilirubin levels in
several populations, as well as other variants of modest effect across the genome. However …

Pharmacokinetics ATV is rapidly absorbed and the peak ATV concentration (Cmax) is
reached between 2 and 2.5 h postdose. ATV absorption is improved when it is taken with …

目的明确Gilbert 综合征患者(Gilbert syndrome, GS) UDP-葡萄糖醛酸基转移酶1A1 基因(UDP-
glucuronyl transferase 1A1 gene, UGT1A1) 致病变异的连锁关系, 进一步明确GS 的遗传机制 …

INTRODUCTION Approximately 73% of persons with HIV who receive antiretroviral therapy
in Cuba are in viral suppression. The non-response of the remaining 27% could be due to …

Atazanavir is indicated for managing human immunodeficiency virus (HIV) infection as part
of a multi-drug regimen (1). While it was once widely recommended as a first-line therapy, it …

Several anti-HIV medications are currently available and used in medical care for HIV-
positive people all over the world. Drug resistance is a global problem that necessitates the …

Background Atazanavir is a protease inhibitor currently recommended for use as a second
line agent in Human Immunodeficiency Virus (HIV) infected patients who have failed therapy …

Le cotrimoxazole, sulfaméthoxazole-triméthoprime (SMX-TMP), est un antibiotique utilisé
chez les patients infectés par le VIH en prophylaxie pour prévenir la survenue des infections …

Background: Prospective studies support the clinical impact of pharmacogenomics (PGx)-
guided prescribing. A sub-set of these drug-gene interactions (DGIs) has been categorized …