Oxidative stress and inflammation in acute and chronic lung injuries

FS Bezerra, M Lanzetti, RT Nesi, AC Nagato, CP Silva… - Antioxidants, 2023 - mdpi.com
Acute and chronic lung injuries are among the leading causes of mortality worldwide. Lung
injury can affect several components of the respiratory system, including the airways …

Perinatal hyperoxia and developmental consequences on the lung‐brain axis

S Obst, J Herz, MA Alejandre Alcazar… - Oxidative medicine …, 2022 - Wiley Online Library
Approximately 11.1% of all newborns worldwide are born preterm. Improved neonatal
intensive care significantly increased survival rates over the last decades but failed to …

When inflammation meets lung development—an update on the pathogenesis of bronchopulmonary dysplasia

L Holzfurtner, T Shahzad, Y Dong, L Rekers… - Molecular and cellular …, 2022 - Springer
Even more than 50 years after its initial description, bronchopulmonary dysplasia (BPD)
remains one of the most important and lifelong sequelae following premature birth …

CXCL10 deficiency limits macrophage infiltration, preserves lung matrix, and enables lung growth in bronchopulmonary dysplasia

DV Hirani, F Thielen, S Mansouri… - Inflammation and …, 2023 - Springer
Preterm infants with oxygen supplementation are at high risk for bronchopulmonary
dysplasia (BPD), a neonatal chronic lung disease. Inflammation with macrophage activation …

[HTML][HTML] Role of sex as a biological variable in neonatal alveolar macrophages

C Leek, A Cantu, S Sonti, MC Gutierrez, L Eldredge… - Redox Biology, 2024 - Elsevier
The lung macrophages play a crucial role in health and disease. Sexual dimorphism
significantly impacts the phenotype and function of tissue-resident macrophages. The …

Exogenous l-fucose attenuates neuroinflammation induced by lipopolysaccharide

X Xu, T Fukuda, J Takai, S Morii, Y Sun, J Liu… - Journal of Biological …, 2024 - ASBMB
α1, 6-Fucosyltransferase (Fut8) catalyzes the transfer of fucose to the innermost GlcNAc
residue of N-glycan to form core fucosylation. Our previous studies showed that …

Hyperoxia prevents the dynamic neonatal increases in lung mesenchymal cell diversity

F Zanini, X Che, NE Suresh, C Knutsen, P Klavina… - Scientific Reports, 2024 - nature.com
Rapid expansion of the pulmonary microvasculature through angiogenesis drives
alveolarization, the final stage of lung development that occurs postnatally and dramatically …

Molecular mechanisms of cell death in bronchopulmonary dysplasia

X Deng, Z Bao, X Yang, Y Mei, Q Zhou, A Chen, R Yu… - Apoptosis, 2023 - Springer
Bronchopulmonary dysplasia (BPD) in neonates is the most common pulmonary disease
that causes neonatal mortality, has complex pathogenesis, and lacks effective treatment. It is …

Phytochemical Composition and Antioxidant and Anti-Inflammatory Activities of Humboldtia sanjappae Sasidh. & Sujanapal, an Endemic Medicinal Plant to the …

J Sidhic, S George, A Alfarhan, R Rajagopal… - Molecules, 2023 - mdpi.com
Ethnomedicinal plants are important sources of drug candidates, and many of these plants,
especially in the Western Ghats, are underexplored. Humboldtia, a genus within the …

Ginsenoside Rb1 reduces oxidative/carbonyl stress damage and ameliorates inflammation in the lung of streptozotocin-induced diabetic rats

H Su, CJ Tian, Y Wang, J Shi, X Chen… - Pharmaceutical …, 2022 - Taylor & Francis
Abstract Context Ginsenoside Rb1 (Rb1) is a biologically active component of ginseng
[Panax ginseng CA Meyer (Araliaceae)]. Objective This study determined the underlying …