This review focuses on the unique clinical and molecular pharmacologic features of
etomidate. Among general anesthesia induction drugs, etomidate is the only imidazole, and …

Abstract Cytochrome P450 (CYP) family 1, 2, and 3 enzymes play an essential role in the
metabolic clearance and detoxification of a myriad of structurally and chemically diverse …

Protein flexibility plays a major role in biomolecular recognition. In many cases, it is not
obvious how molecular structure will change upon association with other molecules. In …

The cytochrome P450s are a superfamily of enzymes that are found in all kingdoms of living
organisms, and typically catalyze the oxidative addition of atomic oxygen to an unactivated …

Tuberculosis remains a leading cause of human mortality. The emergence of strains of
Mycobacterium tuberculosis, the causative agent, that are resistant to the major frontline …

X-ray crystal structures are available for 29 eukaryotic microsomal, chloroplast, or
mitochondrial cytochrome P450s, including two non-monooxygenase P450s. These …

Cytochrome P450 enzymes are renowned for their ability to insert oxygen into an enormous
variety of compounds with a high degree of chemo-and regio-selectivity under mild …

Cytochromes P450 (CYP) from the 2A subfamily are known for their roles in the metabolism
of nicotine, the addictive agent in tobacco, and activation of the tobacco procarcinogen 4 …

Cytochromes P450 (P450s) play a major role in the clearance of drugs, toxins and
environmental pollutants. In addition, metabolism by P450s can result in toxic or …

The structure of the K262R genetic variant of human cytochrome P450 2B6 in complex with
the inhibitor 4-(4-chlorophenyl) imidazole (4-CPI) has been determined using X-ray …