Applications of innovation technologies for personalized cancer medicine: stem cells and gene-editing tools

A Hasanzadeh, A Ebadati, L Dastanpour… - ACS Pharmacology & …, 2023 - ACS Publications
Personalized medicine is a new approach toward safer and even cheaper treatments with
minimal side effects and toxicity. Planning a therapy based on individual properties causes …

VP22 core domain from Herpes simplex virus 1 reveals a surprising structural conservation in both the Alpha- and Gammaherpesvirinae subfamilies

K Hew, SL Dahlroth, LX Pan… - Journal of General …, 2015 - microbiologyresearch.org
The viral tegument is a layer of proteins between the herpesvirus capsid and its outer
envelope. According to phylogenetic studies, only a third of these proteins are conserved …

A hybrid nanovector of suicide gene engineered lentivirus coated with bioreducible polyaminoglycosides for enhancing therapeutic efficacy against glioma

W Fan, M Shao, J Zhang, G Jin, F Liu… - Advanced Functional …, 2019 - Wiley Online Library
An emerging hybrid nanovector integrating the merits of both viral and nonviral vectors has
attracted much attention as the next generation of promising gene vectors to overcome the …

Combined treatment, based on lysomustine administration with mesenchymal stem cells expressing cytosine deaminase therapy, leads to pronounced murine Lewis …

LS Krassikova, SS Karshieva… - The journal of gene …, 2016 - Wiley Online Library
Background The combination of stem cell‐based gene therapy with chemotherapy
comprises an advantageous strategy that results in a reduction of system toxicity effects and …

Ferritin heavy chain as a molecular imaging reporter gene in glioma xenografts

S Cheng, R Mi, Y Xu, G Jin, J Zhang, Y Zhou… - Journal of Cancer …, 2017 - Springer
Purpose The development of glioma therapy in clinical practice (eg, gene therapy) calls for
efficiently visualizing and tracking glioma cells in vivo. Human ferritin heavy chain is a novel …

Herpes simplex virus type 1 VP22-mediated intercellular delivery of PTEN increases the antitumor activity of PTEN in esophageal squamous cell carcinoma cells in …

X Yu, T Li, Y Xia, J Lei, Y Wang… - Oncology …, 2016 - spandidos-publications.com
In the past decade, studies have revealed that the phosphatase and tensin homolog (PTEN)
protein, a tumor suppressor, comprises a potential biological marker and therapeutic target …

Stem cells treatment to combat Cancer and genetic disease: from stem cell therapy to gene-editing correction

F Rahim, B Arjmand, B Larijani, P Goodarzi - Stem cells for cancer and …, 2018 - Springer
Stem cells have a great potential to lead to the creation or growths of specific cells within an
organism. Certain types of stem cells have used to regenerate blood and immune system …

The enhanced efficacy of herpes simplex virus by lentivirus mediated VP22 and cytosine deaminase gene therapy against glioma

R Mi, W Fan, J Ji, C Dong, G Jin, F Liu - Brain Research, 2020 - Elsevier
Despite the comprehensive treatment of surgery following by concurrent
radiochemotherapy, the prognosis of malignant glioma remains unsatisfactory with an awful …

[HTML][HTML] 神经干细胞治疗胶质瘤的研究进展

罗林明, 楚世峰, 姜懿纳, 罗飘, 陈乃宏 - 药学学报, 2017 - html.rhhz.net
神经干细胞具有肿瘤趋向性, 可向肿瘤细胞定向迁移; 神经干细胞能跨越血脑屏障;
而且在肿瘤微环境下, 神经干细胞与肿瘤细胞优先接触, 然后包围靶细胞. 基于以上特性 …

[PDF][PDF] 细胞穿膜肽VP22 增强抑癌蛋白PTEN 在BT549 细胞的表达和分布

余娴, 雷军, 胥正敏, 李婷婷 - 中国药学杂志, 2015 - journal11.magtechjournal.com
目的制备表达细胞穿膜肽融合蛋白PTEN-VP22 的真核表达质粒, 验证细胞穿膜肽VP22
能否增强抑癌蛋白PTEN 在BT549 细胞的表达和分布. 方法构建重组真核表达质粒pcDNA3 …