Elevated cardiovascular risk including stroke, heart failure, and heart attack is present even
after normalization of blood pressure in patients with hypertension. Underlying immune cell …

The teleology of sex differences has been argued since at least as early as Aristotle's
controversial Generation of Animals more than 300 years BC, which reflects the sex bias of …

Hypertension remains the most important modifiable risk factor for the development of
cardiovascular disease. While it is clear that inflammation plays a pivotal role in the …

Most hypertensive cases are primary and heavily associated with modifiable risk factors like
salt intake. Evidence suggests that even small reductions in salt consumption reduce blood …

Hypertension is the primary cause of cardiovascular mortality. Despite multiple existing
treatments, only half of those with the disease achieve adequate control. Therefore …

Emerging evidence has supported a role of inflammation and immunity in the genesis of
hypertension. In humans and experimental models of hypertension, cells of the innate and …

Sepsis, defined as organ dysfunction caused by a dysregulated host-response to infection,
is characterized by immunosuppression. The vasopressor norepinephrine is widely used to …

Inflammation is triggered by stimulation of innate sensors that recognize pathogens,
chemical and physical irritants, and damaged cells subsequently initiating a well …

Salt sensitivity of blood pressure is an independent risk factor for cardiovascular mortality not
only in hypertensive but also in normotensive adults. The diagnosis of salt sensitivity of …

A20, also known as TNF-α-induced protein 3 (TNFAIP3), is an anti-inflammatory protein that
plays an important part in both immune responses and cell death. Impaired A20 function is …