Unraveling the role of toxin-antitoxin systems in Burkholderia pseudomallei: exploring bacterial pathogenesis and interactions within the HigBA families
I Chapartegui-González, JL Stockton… - Microbiology …, 2024 - journals.asm.org
Burkholderia pseudomallei (Bpm) is a Gram-negative intracellular pathogen that causes
melioidosis in humans, a neglected, underreported, and lethal disease that can reach a fatal …
melioidosis in humans, a neglected, underreported, and lethal disease that can reach a fatal …
[HTML][HTML] Exploring Burkholderia pseudomallei-specific bacteriophages: overcoming O-antigen specificity and adaptive mutation in phage tail fiber
P Khrongsee, J Kaewrakmuk, M Alami-Rose… - Frontiers in …, 2024 - frontiersin.org
Introduction Burkholderia pseudomallei, a Gram-negative bacterium inhabiting soil and
fresh water, is the causative agent of melioidosis, a formidable disease in the tropics. The …
fresh water, is the causative agent of melioidosis, a formidable disease in the tropics. The …
Design, synthesis, antimicrobial evaluation, and molecular modeling of new sulfamethoxazole and trimethoprim analogs as potential DHPS/DHFR inhibitors
LMAA Ghany, N Ryad, MS Abdel-Aziz… - Journal of Molecular …, 2024 - Elsevier
Trimethoprim (TMP) and sulfonamides and are typically utilized to hinder the activities of
dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) enzymes …
dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) enzymes …
[HTML][HTML] Adverse reactions to trimethoprim/sulfamethoxazole for melioidosis eradication therapy: An evaluation of frequency and risk factors
GE Martin, J Bramwell, E Gadil, C Woerle… - International Journal of …, 2025 - Elsevier
Trimethoprim/sulfamethoxazole is the first-line agent for oral eradication therapy for
melioidosis but has been associated with toxicity in this context. This study aimed to quantify …
melioidosis but has been associated with toxicity in this context. This study aimed to quantify …
[HTML][HTML] Modeling environmental-born melioidosis dynamics with recurrence: An application of optimal control
HA Engida - Results in Control and Optimization, 2024 - Elsevier
Melioidosis is a significant health problem in tropical and subtropical regions, especially in
Southeast Asia and Northern Australia. Recurrent melioidosis is a major obstacle to …
Southeast Asia and Northern Australia. Recurrent melioidosis is a major obstacle to …