Comparing the aggregation free energy landscapes of amyloid beta (1–42) and amyloid beta (1–40)

W Zheng, MY Tsai, PG Wolynes - Journal of the American …, 2017 - ACS Publications
Using a predictive coarse-grained protein force field, we compute and compare the free
energy landscapes and relative stabilities of amyloid-β protein (1–42) and amyloid-β protein …

Fibril surface-dependent amyloid precursors revealed by coarse-grained molecular dynamics simulation

YW Ma, TY Lin, MY Tsai - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
Amyloid peptides are known to self-assemble into larger aggregates that are linked to the
pathogenesis of many neurodegenerative disorders. In contrast to primary nucleation, recent …

Modeling the game of go by ising Hamiltonian, deep belief networks and common fate graphs

A Rojas-Domínguez, D Barradas-Baustista… - IEEE …, 2019 - ieeexplore.ieee.org
Three different models of the game of Go are developed by establishing an analogy
between this game and physical systems susceptible to analysis under the well-known Ising …

Role of physical nucleation theory in understanding conformational conversion between pathogenic and nonpathogenic aggregates of low-complexity amyloid …

MY Tsai - Research on Chemical Intermediates, 2019 - Springer
Amyloid-forming proteins aggregate within and between neuronal cells, and the resulting
deposits are associated with neurodegenerative diseases. The amyloidogenic property of …

Go game formal revealing by Ising model

M Alvarado, A Yee, C Villarreal - arXiv preprint arXiv:1710.07360, 2017 - arxiv.org
Go gaming is a struggle for territory control between rival, black and white, stones on a
board. We model the Go dynamics in a game by means of the Ising model whose interaction …

Thermodynamics and Kinetics of Protein Folding and Aggregation

MY Tsai, JM Yuan, SH Lin - … Studies on Folding, Misfolding, and Self …, 2017 - World Scientific
Thermodynamic and kinetic properties of proteins affect their folding and aggregation
processes, which are responsible for a range of biological functions in cells. This chapter …