Neurobiology of comorbid post‐traumatic stress disorder and alcohol‐use disorder

NW Gilpin, JL Weiner - Genes, Brain and Behavior, 2017 - Wiley Online Library
Post‐traumatic stress disorder (PTSD) and alcohol‐use disorder (AUD) are highly comorbid
in humans. Although we have some understanding of the structural and functional brain …

Rodent models of impaired fear extinction

N Singewald, A Holmes - Psychopharmacology, 2019 - Springer
The measurement of Pavlovian forms of fear extinction offers a relatively simple behavioral
preparation that is nonetheless tractable, from a translational perspective, as an approach to …

Adolescence alcohol exposure impairs fear extinction and alters medial prefrontal cortex plasticity

K Lawson, MJ Scarlata, WC Cho, C Mangan… - …, 2022 - Elsevier
After experiencing a traumatic event people often turn to alcohol to cope with symptoms. In
those with post-traumatic stress disorder (PTSD) and a co-occurring alcohol use disorder …

Impairments in expression of devaluation in a Pavlovian goal-tracking task, but not a free operant devaluation task, after fentanyl exposure in female rats

CL Pickens, A Hougham, J Kim, C Wang… - Behavioural Brain …, 2024 - Elsevier
In laboratory animals, there are numerous demonstrations that past exposure to drugs of
abuse can lead to devaluation impairments weeks after the final drug exposure, with the …

Ethanol modulation of cortico-basolateral amygdala circuits: Neurophysiology and behavior

BA McCool - Neuropharmacology, 2021 - Elsevier
This review highlights literature relating the anatomy, physiology, and behavioral
contributions by projections between rodent prefrontal cortical areas and the basolateral …

Decoding the language of fear: Unveiling objective and subjective indicators in rodent models through a systematic review and meta-analysis

L Bao, J Rao, D Yu, B Zheng, B Yin - Neuroscience & Biobehavioral …, 2024 - Elsevier
While rodent models are vital for studying mental disorders, the underestimation of construct
validity of fear indicators has led to limitations in translating to effective clinical treatments …

Chemogenetic stimulation of the infralimbic cortex reverses alcohol-induced fear memory overgeneralization

MJ Scarlata, SH Lee, D Lee, SE Kandigian, AJ Hiller… - Scientific reports, 2019 - nature.com
Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are often comorbid.
Drinking tends to increase following trauma, which may exacerbate PTSD-related …

Design and development of a robotic predator as a stimulus in conditioned place aversion for the study of the effect of ethanol and citalopram in zebrafish

RJG Clément, S Macrì, M Porfiri - Behavioural brain research, 2020 - Elsevier
Zebrafish are becoming a species of choice in psychopharmacology, laying a promising
path to refined pharmacological manipulations and high-throughput behavioral …

Repeated cocaine exposure prior to fear conditioning induces persistency of PTSD-like symptoms and enhancement of hippocampal and amygdala cell density in …

A Lguensat, C Montanari, C Vielle, M Bennis… - Brain Structure and …, 2021 - Springer
Pre-and post-trauma drug use can interfere with recovery from post-traumatic stress disorder
(PTSD). However, the biological underpinnings of this interference are poorly understood …

Individual differences in conditioned fear are associated with levels of adolescent/early adult alcohol consumption and instrumental extinction

A Pajser, M Breen, H Fisher, CL Pickens - Behavioural brain research, 2018 - Elsevier
Previous research has shown a relationship between alcohol exposure and conditioned
fear, but the nature of this relationship remains unclear. We determined whether chronic …