The pulmonary circulation is a low-resistance, low-pressure, and high-compliance system
that allows the lungs to receive the entire cardiac output. Pulmonary arterial pressure is a …

Myocardial infarction with nonobstructive coronary arteries (MINOCA) remains a puzzling
clinical entity. It is characterized by clinical evidence of myocardial infarction (MI) with normal …

Despite encouraging preclinical data, therapies to reduce ARDS mortality remains a globally
unmet need, including during the COVID-19 pandemic. We previously identified …

Visfatin/nicotinamide phosphoribosyltransferase (NAMPT) is an adipokine expressed
predominately in visceral fat tissues. High circulating levels of visfatin/NAMPT have been …

Although the progression of non‐alcoholic fatty liver disease (NAFLD) from steatosis to
steatohepatitis (NASH) and cirrhosis remains poorly understood, a critical role for …

Background: Numerous potential ARDS therapeutics, based upon preclinical successful
rodent studies that utilized LPS challenge without mechanical ventilation, have failed in …

ABSTRACT Approximately 15%-20% of patients infected with SARS-CoV-2 coronavirus
(COVID-19) progress beyond mild and self-limited disease to require supplemental oxygen …

The aryl hydrocarbon receptor (AHR) is a basic helix-loop-helix transcription factor that
binds diverse endogenous and xenobiotic ligands, which regulate AHR stability …

Myocardial infarction (MI) triggers adverse ventricular remodeling (VR), cardiac fibrosis, and
subsequent heart failure. Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) is …

We previously reported heightened expression of the human endogenous retroviral protein
HERV-K deoxyuridine triphosphate nucleotidohydrolase (dUTPase) in circulating …