Steroid sulfatase (STS) is responsible for the hydrolysis of aryl and alkyl steroid sulfates and
therefore has a pivotal role in regulating the formation of biologically active steroids. The …

Breast cancer, a most common malignancy in women, was known to be associated with
steroid hormone estrogen. The discovery of estrogen receptor (ER) gave us not only a …

The great majority of breast cancers are in their early stage hormone-dependent and it is
well accepted that estradiol (E2) plays an important role in the genesis and evolution of this …

In 1980 sulfamic acid and its N-substituted derivatives were reviewed in Chemical Reviews,
1 effectively updating an earlier 1940 review 2 also in Chemical Reviews. In 1991 the …

We report a Rh-catalyzed, enantioselective silylation of arene C–H bonds directed by a
(hydrido) silyl group.(Hydrido) silyl ethers that are formed in situ by hydrosilylation of …

Benzophenone, an aryl ketone, is used primarily as a photoinitiator and fragrance enhancer.
Groups of 50 male and 50 female F344 rats and B6C3 F1 mice were fed diets containing 0 …

In 1994, following work from this laboratory, it was reported that estrone-3-O-sulfamate
irreversibly inhibits a new potential hormone-dependent cancer target steroid sulfatase …

The steroid sulfatase (STS) plays a major role in the regulation of steroid hormone
concentrations in several human tissues and target organs and therefore, represents an …

To explore aromatase inhibition and to broaden the structural diversity of dual aromatase−
sulfatase inhibitors (DASIs), we introduced the steroid sulfatase (STS) inhibitory …

By introducting the steroid sulfatase inhibitory pharmacophore into aromatase inhibitor 1
(YM511), two series of single agent dual aromatase− sulfatase inhibitors (DASIs) were …