Chemically modified and conjugated antimicrobial peptides against superbugs

W Li, F Separovic, NM O'Brien-Simpson… - Chemical Society …, 2021 - pubs.rsc.org
Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050,
will lead to more deaths from bacterial infections than cancer. New antimicrobial agents …

Escherichia coli in Europe: An Overview

N Allocati, M Masulli, MF Alexeyev, C Di Ilio - International journal of …, 2013 - mdpi.com
Escherichia coli remains one of the most frequent causes of several common bacterial
infections in humans and animals. E. coli is the prominent cause of enteritis, urinary tract …

Antimicrobial peptides: an overview of a promising class of therapeutics

A Giuliani, G Pirri, S Nicoletto - Open Life Sciences, 2007 - degruyter.com
Antibiotic resistance is increasing at a rate that far exceeds the pace of new development of
drugs. Antimicrobial peptides, both synthetic and from natural sources, have raised interest …

Recent developments in antimicrobial-peptide-conjugated gold nanoparticles

U Rajchakit, V Sarojini - Bioconjugate chemistry, 2017 - ACS Publications
The escalation of multidrug-resistant pathogens has created a dire need to develop novel
ways of addressing this global therapeutic challenge. Because of their antimicrobial …

[HTML][HTML] Alpha-helical antimicrobial peptides—Using a sequence template to guide structure–activity relationship studies

I Zelezetsky, A Tossi - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2006 - Elsevier
An important class of cytolytic antimicrobial peptides (AMPs) assumes an amphipathic, α-
helical conformation that permits efficient interaction with biological membranes. Host …

Designer peptide and protein dendrimers: a cross-sectional analysis

R Sapra, RP Verma, GP Maurya, S Dhawan… - Chemical …, 2019 - ACS Publications
Dendrimers have attracted immense interest in science and technology due to their unique
chemical structure that offers a myriad of opportunities for researchers. Dendritic design …

Challenges and future prospects of antibiotic therapy: from peptides to phages utilization

SM Mandal, A Roy, AK Ghosh, TK Hazra… - Frontiers in …, 2014 - frontiersin.org
Bacterial infections are raising serious concern across the globe. The effectiveness of
conventional antibiotics is decreasing due to global emergence of multi-drug-resistant …

Natural antimicrobial peptides as inspiration for design of a new generation antifungal compounds

M Bondaryk, M Staniszewska, P Zielińska… - Journal of fungi, 2017 - mdpi.com
Invasive fungal infections are associated with high mortality rates, despite appropriate
antifungal therapy. Limited therapeutic options, resistance development and the high …

Exploiting dendrimer multivalency to combat emerging and re-emerging infectious diseases

MA Mintzer, EL Dane, GA O'Toole… - Molecular …, 2012 - ACS Publications
The emergence and re-emergence of bacterial strains that are resistant to current antibiotics
reveal the clinical need for new agents that possess broad-spectrum antibacterial activity …

Antibacterial activities of poly (amidoamine) dendrimers terminated with amino and poly (ethylene glycol) groups

MK Calabretta, A Kumar, AM McDermott… - …, 2007 - ACS Publications
Poly (amidoamine)(PAMAM) dendrimer derivatives have been investigated for their
biological applications, especially for delivery of drugs, including antimicrobial drugs to …