Twelve regulated cell death programs have been described. We review in detail the basic
biology of nine including death receptor-mediated apoptosis, death receptor-mediated …

Neutrophil extracellular trap (NET) formation, first described in 2004 as a previously
unknown strategy of neutrophils to fight microbes, has attracted an increasing interest in the …

The ongoing worldwide increase in life expectancy portends a rising prevalence of age-
related cardiovascular (CV) diseases in the coming decades that demands a deeper …

COVID-19 is a clinical syndrome ranging from mild symptoms to severe pneumonia that
often leads to respiratory failure, need for mechanical ventilation, and death. Most of the lung …

Hypertension is associated with immune cells activation and their migration into the kidney,
vasculature, heart and brain. These inflammatory mechanisms are critical for blood pressure …

After ischemic stroke, the integrity of the blood-brain barrier is compromised. Peripheral
immune cells, including neutrophils, T cells, B cells, dendritic cells, and macrophages …

Inflammation contributes centrally to cardiovascular diseases, and anti-inflammatory
treatments can reduce cardiovascular events. The JAK–STAT pathway is an emerging target …

Metformin is one of the most widely prescribed hypoglycemic drugs and has the potential to
treat many diseases. More and more evidence shows that metformin can regulate the …

Innate immunity and chronic inflammation are involved in atherosclerosis and
atherothrombosis, leading to target organ damage in essential hypertension (EH). However …

Neutrophils are first-line responders of the innate immune system. Following myocardial
infarction (MI), neutrophils are quickly recruited to the ischemic region, where they initiate …