Abstract Systems neuroscience approaches with a focus on large-scale brain organization
and network analysis are advancing foundational knowledge of how cognitive control …

The collective activity of a population of neurons, beyond the properties of individual cells, is
crucial for many brain functions. A fundamental question is how activity correlations between …

Invasive and non-invasive brain stimulation methods are widely used in neuroscience to
establish causal relationships between distinct brain regions and the sensory, cognitive and …

Noradrenaline released from the locus coeruleus (LC) is a ubiquitous neuromodulator,,–that
has been linked to multiple functions including arousal,,–, action and sensory gain,–, and …

A major shift is happening within neurophysiology: a population doctrine is drawing level
with the single-neuron doctrine that has long dominated the field. Population-level ideas …

The curse of dimensionality plagues models of reinforcement learning and decision making.
The process of abstraction solves this by constructing variables describing features shared …

Neural activity throughout the cortex is correlated with perceptual decisions, but inactivation
studies suggest that only a small number of areas are necessary for these behaviors. Here …

Persistent neuronal spiking has long been considered the mechanism underlying working
memory, but recent proposals argue for alternative 'activity-silent'substrates. Using monkey …

Sensory areas are spontaneously active in the absence of sensory stimuli. This
spontaneous activity has long been studied; however, its functional role remains largely …

Interactions between the prefrontal cortex (PFC) and mediodorsal thalamus are critical for
cognitive flexibility, yet the underlying computations are unknown. To investigate …