Discovery of novel multidrug resistance protein 4 (MRP4) inhibitors as active agents reducing resistance to anticancer drug 6-Mercaptopurine (6-MP) by structure and …
Multidrug resistance protein 4 (MRP4/ABCC4) is an ATP-binding cassette (ABC) transporter.
It is associated with multidrug resistance (MDR), which is becoming a growing challenge to …
It is associated with multidrug resistance (MDR), which is becoming a growing challenge to …
Structural patterns of the human ABCC4/MRP4 exporter in lipid bilayers rationalize clinically observed polymorphisms
The ABCC4/MRP4 exporter has a clinical impact on membrane transport of a broad range of
xenobiotics. It is expressed at key locations for drug disposition or effects such as in the liver …
xenobiotics. It is expressed at key locations for drug disposition or effects such as in the liver …