The ability of skin to act as a barrier is primarily determined by cells that maintain the
continuity and integrity of skin and restore it after injury. Cutaneous wound healing in adult …

Integrins are transmembrane receptors that have been implicated in the biology of various
human physiological and pathological processes. These molecules facilitate cell …

Laminin, as a key component of the basement membrane extracellular matrix (ECM),
regulates tissue morphogenesis. Here, we show that multiple laminin isoforms …

Tumor cells can evade chemotherapy by acquiring resistance to apoptosis. We investigated
the molecular mechanism whereby malignant and nonmalignant mammary epithelial cells …

An essential feature of a healed wound is the restoration of an intact epidermal barrier
through wound epithelialization, also known as re-epithelialization. The directed migration of …

Mammalian epidermis is renewed throughout life by proliferation of a multipotential stem cell
population and terminal differentiation of stem cell progeny. In recent years, extracellular …

The epidermis functions in skin as first defense line or barrier against environmental
impacts, resting on extracellular matrix (ECM) of the dermis underneath. Both compartments …

Wound healing is a critical process for the organism. The attempt of this chapter is to
critically summarize the recent advancements in the wound-healing process. Because of the …

Background/aims: The influence of mechanical forces on skin has been examined since
1861 when Langer first reported the existence of lines of tension in cadaver skin. Internal …

Laminins are a family of trimeric glycoproteins present in the extracellular matrix and the
major constituents of basement membranes. Integrins are αβ transmembrane receptors that …