Mammalian genomes encode genes for more than 30 phospholipase A2s (PLA2s) or
related enzymes, which are subdivided into several classes including low-molecular-weight …

Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane
glycerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including …

Phospholipase A2 (PLA2) constitutes a growing superfamily of lipolytic enzymes, and to
date, at least 19 distinct enzymes have been found in mammals. This class of enzymes has …

Snake venom phospholipases A2 (PLA2) show a remarkable functional diversity. Among
their toxic activities, some display the ability to cause rapid necrosis of skeletal muscle fibers …

Studies on the heterogeneity and plasticity of macrophage populations led to the
identification of two major polarization states: classically activated macrophages or M1 …

In macrophages and other major immunoinflammatory cells, two phospholipase A 2 (PLA 2)
enzymes act in concert to mobilize arachidonic acid (AA) for immediate PG synthesis …

Among the emerging phospholipase A2 (PLA2) superfamily, the secreted PLA2 (sPLA2)
family consists of low-molecular-mass, Ca2+-requiring extracellular enzymes with a His-Asp …

The bacterial tripeptide formyl-Met-Leu-Phe (fMLP) induces the secretion of enzyme (s) with
phospholipase A 2 (PLA 2) activity from human neutrophils. We show that circulating human …

Abstract Secreted phospholipases A 2 (sPLA 2) are enzymes released in plasma and
extracellular fluids during inflammatory diseases. Because human group IB and X sPLA 2 s …

Les cellules de mammifères ont acquis des voies spécifiques pour l'incorporation, la
redistribution et la libération de l'acide arachidonique. Les voies de l'acyltransférase et de la …