DNA recognition and induced genome modification by a hydroxymethyl-γ tail-clamp peptide nucleic acid
Peptide nucleic acids (PNAs) can target and stimulate recombination reactions in genomic
DNA. We have reported that γPNA oligomers possessing the diethylene glycol γ-substituent …
DNA. We have reported that γPNA oligomers possessing the diethylene glycol γ-substituent …
Walking through the wonder years of artificial DNA: peptide nucleic acid
Abstract Peptide Nucleic Acid (PNA) serves as an artificial functional analog of DNA. Being
immune to enzymatic degradation and possessing strong affinity towards DNA and RNA, it is …
immune to enzymatic degradation and possessing strong affinity towards DNA and RNA, it is …
Development of the Right-and Left-Handed Gamma Peptide Nucleic Acid Building Blocks for On-Resin Chemical Functionalization
Gamma peptide nucleic acids (PNAs) are a promising class of nucleic acid mimics that
adopt either a right-or left-handed helical motif as individual strands and hybridize to DNA or …
adopt either a right-or left-handed helical motif as individual strands and hybridize to DNA or …
Bifunctional small molecule-oligonucleotide hybrid as microRNA inhibitor
Abstract miRNAs are key regulators of various biological processes. Dysregulation of
miRNA is linked to many diseases. Development of miRNA inhibitor has implication in …
miRNA is linked to many diseases. Development of miRNA inhibitor has implication in …
Rapid Synthesis of Propargyl‐γ‐Modified Peptide Nucleic Acid Monomers for Late‐Stage Functionalization of Oligomers
M López‐Tena, EE Watson, P Romanens… - Helvetica Chimica …, 2023 - Wiley Online Library
The exceptional hybridization properties of peptide nucleic acids (PNAs) coupled with the
ease of their synthesis has made this artificial nucleic acid mimetic a desirable platform for …
ease of their synthesis has made this artificial nucleic acid mimetic a desirable platform for …
Synthesis and Characterization of Optically Pure Gamma‐PNA Backbones by SIBX‐Mediated Reductive Amination
A Periyalagan, YT Kim, IS Hong - Bulletin of the Korean …, 2021 - Wiley Online Library
Chiral peptide nucleic acid (PNA) is a derivative of regular PNA by introducing a chiral
center to its backbone, and is known to bind more strongly to DNA or RNA than regular PNA …
center to its backbone, and is known to bind more strongly to DNA or RNA than regular PNA …