Where protein structure and cell diversity meet
JA Holguin-Cruz, LJ Foster, J Gsponer - Trends in Cell Biology, 2022 - cell.com
Protein–protein interaction networks–interactomes–are charted with the hope to understand
how phenotypes emerge and how they are altered in disease states. Early efforts to map …
how phenotypes emerge and how they are altered in disease states. Early efforts to map …
SRC homology 3 domains: Multifaceted binding modules
The assembly of complexes following the detection of extracellular signals is often controlled
by signaling proteins comprising multiple peptide binding modules. The SRC homology …
by signaling proteins comprising multiple peptide binding modules. The SRC homology …
Nanopore sequencing reveals endogenous NMD-targeted isoforms in human cells
Background Nonsense-mediated mRNA decay (NMD) is a eukaryotic, translation-
dependent degradation pathway that targets mRNAs with premature termination codons and …
dependent degradation pathway that targets mRNAs with premature termination codons and …
Application of deep learning algorithm on whole genome sequencing data uncovers structural variants associated with multiple mental disorders in African American …
Mental disorders present a global health concern, while the diagnosis of mental disorders
can be challenging. The diagnosis is even harder for patients who have more than one type …
can be challenging. The diagnosis is even harder for patients who have more than one type …
RNA structure profiling at single-cell resolution reveals new determinants of cell identity
RNA structure is critical for multiple steps in gene regulation. However, how the structures of
transcripts differ both within and between individual cells is unknown. Here we develop a …
transcripts differ both within and between individual cells is unknown. Here we develop a …
Srsf1 and Elavl1 act antagonistically on neuronal fate choice in the developing neocortex by controlling TrkC receptor isoform expression
AI Weber, S Parthasarathy, E Borisova… - Nucleic Acids …, 2023 - academic.oup.com
The seat of higher-order cognitive abilities in mammals, the neocortex, is a complex
structure, organized in several layers. The different subtypes of principal neurons are …
structure, organized in several layers. The different subtypes of principal neurons are …
Thermoregulated transcriptomics: the molecular basis and biological significance of temperature-dependent alternative splicing
T Haltenhof, M Preußner, F Heyd - Biochemical Journal, 2024 - portlandpress.com
Temperature-dependent alternative splicing (AS) is a crucial mechanism for organisms to
adapt to varying environmental temperatures. In mammals, even slight fluctuations in body …
adapt to varying environmental temperatures. In mammals, even slight fluctuations in body …
Identification of Noncoding Functional Regulatory Variants of STIM1 Gene in Idiopathic Pulmonary Arterial Hypertension
B Liu, CJ Wen, G Zhou, YP Wei, Z Wu, T Zhang… - …, 2024 - ahajournals.org
BACKGROUND: STIM1 (stromal interaction molecule 1) regulates store-operated calcium
entry and is involved in pulmonary artery vasoconstriction and pulmonary artery smooth …
entry and is involved in pulmonary artery vasoconstriction and pulmonary artery smooth …
[HTML][HTML] Alternative splicing and liver disease
M Baralle, FE Baralle - Annals of hepatology, 2021 - Elsevier
Alternative splicing produces complex and dynamic changes in the protein isoforms that are
necessary for the proper biological functioning of the metabolic pathways involved in liver …
necessary for the proper biological functioning of the metabolic pathways involved in liver …
YBX1 mediates alternative splicing and maternal mRNA decay during pre-implantation development
Background In mammals, maternal gene products decay and zygotic genome activation
(ZGA) during maternal to zygotic transition (MZT) is critical for the early embryogenesis. Y …
(ZGA) during maternal to zygotic transition (MZT) is critical for the early embryogenesis. Y …