Enterovirus-associated hand-foot and mouth disease and neurological complications in Japan and the rest of the world

G Gonzalez, MJ Carr, M Kobayashi, N Hanaoka… - International journal of …, 2019 - mdpi.com
Enteroviruses (EVs) are responsible for extremely large-scale, periodic epidemics in
pediatric cohorts, particularly in East and Southeast Asia. Clinical presentation includes a …

Recombination in enteroviruses, a multi-step modular evolutionary process

C Muslin, A Mac Kain, M Bessaud, B Blondel… - Viruses, 2019 - mdpi.com
RNA recombination is a major driving force in the evolution and genetic architecture shaping
of enteroviruses. In particular, intertypic recombination is implicated in the emergence of …

The Picornaviridae Family: Knowledge Gaps, Animal Models, Countermeasures, and Prototype Pathogens

R Andino, K Kirkegaard, A Macadam… - The Journal of …, 2023 - academic.oup.com
Picornaviruses are nonenveloped particles with a single-stranded RNA genome of positive
polarity. This virus family includes poliovirus, hepatitis A virus, rhinoviruses, and …

Contemporary circulating enterovirus D68 strains have acquired the capacity for viral entry and replication in human neuronal cells

DM Brown, AM Hixon, LM Oldfield, Y Zhang, M Novotny… - MBio, 2018 - Am Soc Microbiol
ABSTRACT Enterovirus D68 (EV-D68) has historically been associated with respiratory
illnesses. However, in the summers of 2014 and 2016, EV-D68 outbreaks coincided with a …

[HTML][HTML] Metatranscriptomics to characterize respiratory virome, microbiome, and host response directly from clinical samples

SV Rajagopala, NG Bakhoum, SB Pakala, MH Shilts… - Cell reports …, 2021 - cell.com
We developed a metatranscriptomics method that can simultaneously capture the
respiratory virome, microbiome, and host response directly from low biomass samples …

Epidemiology and sequence-based evolutionary analysis of circulating non-polio enteroviruses

DM Brown, Y Zhang, RH Scheuermann - Microorganisms, 2020 - mdpi.com
Enteroviruses (EVs) are positive-sense RNA viruses, with over 50,000 nucleotide
sequences publicly available. While most human infections are typically associated with …

Genomic epidemiology of coxsackievirus A16 in mainland of China, 2000–18

Z Han, Y Song, J Xiao, L Jiang, W Huang, H Wei… - Virus …, 2020 - academic.oup.com
Hand, foot, and mouth disease (HFMD), which is a frequently reported and concerning
disease worldwide, is a severe burden on societies globally, especially in the countries of …

Enterovirus D68 molecular and cellular biology and pathogenesis

MJ Elrick, A Pekosz, P Duggal - Journal of Biological Chemistry, 2021 - ASBMB
In recent years, enterovirus D68 (EV-D68) has advanced from a rarely detected respiratory
virus to a widespread pathogen responsible for increasing rates of severe respiratory illness …

Molecular evolution and the global reemergence of enterovirus D68 by genome-wide analysis

YN Gong, SL Yang, SR Shih, YC Huang, PY Chang… - Medicine, 2016 - journals.lww.com
Abstract Human enterovirus D68 (EV-D68) was first reported in the United States in 1962;
thereafter, a few cases were reported from 1970 to 2005, but 2 outbreaks occurred in the …

Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease

MR Vogt, J Fu, N Kose, LE Williamson… - Science …, 2020 - science.org
Enterovirus D68 (EV-D68) causes outbreaks of respiratory illness, and there is increasing
evidence that it causes outbreaks of acute flaccid myelitis (AFM). There are no licensed …