Thioflavin T (ThT) has been widely used to investigate amyloid formation since 1989. While
concerns have recently been raised about its use as a probe specific for amyloid, ThT still …

Recent times have witnessed an upsurge in the incidence of neurodegenerative disorders
such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Prion disease, and …

Circular dichroism (CD) spectroscopy is a widely used method to study the protein
secondary structure. However, for decades, the general opinion was that the correct …

Understanding the atomistic resolution changes during the self-assembly of amyloid
peptides or proteins is important to develop compounds or conditions to alter the …

Dietary consumption of Trp via protein-based foods is essential for the maintenance of
crucial metabolic processes including the synthesis of proteins and several vital metabolites …

The molecular design of peptide-assembled nanostructures relies on extensive knowledge
pertaining to the relationship between conformational features of peptide constituents and …

Conspectus Huntington's disease (HD) is a progressive, familial neurodegenerative disease
triggered by the expansion of a polyglutamine (polyQ) track in the protein huntingtin (htt) …

Misfolded amyloid-β (Aβ) is the key biomarker of Alzheimer's disease (AD), and discoveries
of fluorescence chemicals visualizing such Aβ aggregates in the brain have made major …

Aggregation of amyloid-β (Aβ42) protein is one hallmark of Alzheimer's disease, and the
conformations of the smallest Aβ42 oligomers are largely unknown. Here, we explore the …

In Huntington disease (HD), an expanded polyglutamine (polyQ> 37) sequence within
huntingtin (htt) exon1 leads to enhanced disease risk. It has proved difficult, however, to …