HER3 in cancer: from the bench to the bedside
L Gandullo-Sánchez, A Ocaña, A Pandiella - Journal of Experimental & …, 2022 - Springer
The HER3 protein, that belongs to the ErbB/HER receptor tyrosine kinase (RTK) family, is
expressed in several types of tumors. That fact, together with the role of HER3 in promoting …
expressed in several types of tumors. That fact, together with the role of HER3 in promoting …
Thirty years of HER3: from basic biology to therapeutic interventions
HM Haikala, PA Jänne - Clinical Cancer Research, 2021 - AACR
HER3 is a pseudokinase member of the EGFR family having a role in both tumor
progression and drug resistance. Although HER3 was discovered more than 30 years ago …
progression and drug resistance. Although HER3 was discovered more than 30 years ago …
[HTML][HTML] Understanding the biology of HER3 receptor as a therapeutic target in human cancer
HER3 belongs to the human epidermal growth factor receptor (HER) family which also
includes HER1/EGFR/erbB1, HER2/erbB2, and HER4/erbB4. As a unique member of the …
includes HER1/EGFR/erbB1, HER2/erbB2, and HER4/erbB4. As a unique member of the …
Systems biology of angiogenesis signaling: Computational models and omics
Angiogenesis is a highly regulated multiscale process that involves a plethora of cells, their
cellular signal transduction, activation, proliferation, differentiation, as well as their …
cellular signal transduction, activation, proliferation, differentiation, as well as their …
NRG1 and NRG2 fusion positive solid tumor malignancies: a paradigm of ligand-fusion oncogenesis
M Nagasaka, SHI Ou - Trends in cancer, 2022 - cell.com
Neuregulins (NRGs) are a family of six related physiological ligands all containing a
receptor-binding epidermal growth factor (EGF)-like domain that mediate their binding to …
receptor-binding epidermal growth factor (EGF)-like domain that mediate their binding to …
The Anti-HER3 mAb Seribantumab Effectively Inhibits Growth of Patient-Derived and Isogenic Cell Line and Xenograft Models with Oncogenic NRG1 Fusions
I Odintsov, AJW Lui, WJ Sisso, E Gladstone, Z Liu… - Clinical Cancer …, 2021 - AACR
Purpose: Oncogenic fusions involving the neuregulin 1 (NRG1) gene are found in
approximately 0.2% of cancers of diverse histologies. The resulting chimeric NRG1 proteins …
approximately 0.2% of cancers of diverse histologies. The resulting chimeric NRG1 proteins …
The tissue proteome in the multi-omic landscape of kidney disease
MM Rinschen, J Saez-Rodriguez - Nature Reviews Nephrology, 2021 - nature.com
Kidney research is entering an era of 'big data'and molecular omics data can provide
comprehensive insights into the molecular footprints of cells. In contrast to transcriptomics …
comprehensive insights into the molecular footprints of cells. In contrast to transcriptomics …
Evaluation framework for systems models
S Braakman, P Pathmanathan… - CPT: pharmacometrics & …, 2022 - Wiley Online Library
As decisions in drug development increasingly rely on predictions from mechanistic systems
models, assessing the predictive capability of such models is becoming more important …
models, assessing the predictive capability of such models is becoming more important …
[HTML][HTML] ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma
F De Bacco, F Orzan, J Erriquez, E Casanova… - Cell Reports, 2021 - cell.com
In glioblastoma (GBM), the most frequent and lethal brain tumor, therapies suppressing
recurrently altered signaling pathways failed to extend survival. However, in patient subsets …
recurrently altered signaling pathways failed to extend survival. However, in patient subsets …
Randomized phase II trial of seribantumab in combination with erlotinib in patients with EGFR Wild‐type non‐small cell lung cancer
LV Sequist, JE Gray, WA Harb, A Lopez‐Chavez… - The …, 2019 - academic.oup.com
Abstract Background Seribantumab (MM‐121) is a fully human IgG2 monoclonal antibody
that binds to human epidermal growth factor receptor 3 (HER3/ErbB3) to block heregulin …
that binds to human epidermal growth factor receptor 3 (HER3/ErbB3) to block heregulin …