Chemistry and biology of monoterpene indole alkaloid biosynthesis - Natural Product Reports
(RSC Publishing) DOI:10.1039/B512615K Royal Society of Chemistry View PDF …

The Catharanthus (or Vinca) alkaloids comprise a group of about 130 terpenoid indole
alkaloids. Vinblastine is now marketed for more than 40 years as an anticancer drug and …

Alkaloids represent a highly diverse group of compounds that are related only by the
occurrence of a nitrogen atom in a heterocyclic ring. Plants are estimated to produce …

▪ Abstract Recent advances in the cell, developmental, and molecular biology of alkaloid
biosynthesis have heightened our appreciation for the complexity and importance of plant …

Plants produce unique natural products as a result of gene mutation and subsequent
adaptation of metabolic pathways to create new secondary metabolites. However, their …

In situ RNA hybridization and immunocytochemistry were used to establish the cellular
distribution of monoterpenoid indole alkaloid biosynthesis in Madagascar periwinkle …

Cytochromes P450 catalyse extremely diverse and often complex regiospecific and/or
stereospecific reactions in the biosynthesis or catabolism of plant bioactive molecules …

Alkaloids represent a large and diverse group of compounds that are related by the
occurrence of a nitrogen atom within a heterocyclic backbone. Unlike other types of …

Catharanthus roseus is still the only source for the powerful antitumour drugs vinblastine
and vincristine. Some other pharmaceutical compounds from this plant, ajmalicine and …

The gene encoding acetyl CoA: deacetylvindoline 4‐O‐acetyltransferase (DAT)(EC 2.3.
1.107) which catalyzes the last step in vindoline biosynthesis was isolated and …