The adult human adrenal cortex produces steroid hormones that are crucial for life,
supporting immune response, glucose homeostasis, salt balance and sexual maturation. It …

Primary aldosteronism is the most common single cause of hypertension and is potentially
curable when only one adrenal gland is the culprit. The importance of primary aldosteronism …

Genetic studies have examined body-shape measures adjusted for body mass index (BMI),
while allometric indices are additionally adjusted for height. We performed the first genome …

Most aldosterone-producing adenomas (APAs) have gain-of-function somatic mutations of
ion channels or transporters. However, their frequency in aldosterone-producing cell …

Childhood neuroblastoma has a remarkable variability in outcome. Age at diagnosis is one
of the most important prognostic factors, with children less than 1 year old having favorable …

Evolution has resulted in profound differences between males and females that extend to
non-reproductive organs and are reflected in the susceptibility and progression of diseases …

The adrenal glands synthesize and release essential steroid hormones such as cortisol and
aldosterone, but many aspects of human adrenal gland development are not well …

The identification of several germline and somatic ion channel mutations in aldosterone-
producing adenomas (APAs) and detection of cell clusters that can be responsible for …

Spatiotemporal control of Wnt signaling is essential for the development and homeostasis of
many tissues. The transmembrane E3 ubiquitin ligases ZNRF3 (zinc and ring finger 3) and …

Adrenal cortex physiology relies on functional zonation, essential for production of
aldosterone by outer zona glomerulosa (ZG) and glucocorticoids by inner zona fasciculata …