Some members of the Firmicutes phylum, including many members of the human gut
microbiota, are able to differentiate a dormant and highly resistant cell type, the endospore …

Clostridioides difficile is a Gram-positive opportunistic pathogen that results in 220,000
infections, 12,000 deaths, and upwards of $1 billion in medical costs in the United States …

Clostridioides difficile is a Gram-positive opportunistic pathogen responsible for 250,000
hospital-associated infections, 12,000 hospital-associated deaths, and $1 billion in medical …

The ability of bacterial pathogens to establish recurrent and persistent infections is
frequently associated with their ability to form biofilms. Clostridioides difficile infections have …

Introduction Clostridioides difficile infection (CDI), as well as its etiology and pathogenesis,
have been extensively investigated. However, the absence of suitable CDI animal models …

The intestinal pathogen Clostridioides difficile encodes roughly 50 TCS, but very few have
been characterized in terms of their activating signals or their regulatory roles. AG Pannullo …

The two‐component regulatory system (TCS) is a major regulatory system in bacteria that
occurs in response to environmental changes and involves the sensor histidine kinase (HK) …

Biofilm-associated infections continue to be an increasing global public health problem. The
biofilm matrix that encases the bacterial cells within biofilms serves as a protective barrier …

Clostridioides difficile is the most common cause of hospital-acquired diarrhea, causing~
250,000 infections and~ 13,000 deaths in the US each year, with an estimated annual …