Technology of deep brain stimulation: current status and future directions
Deep brain stimulation (DBS) is a neurosurgical procedure that allows targeted circuit-based
neuromodulation. DBS is a standard of care in Parkinson disease, essential tremor and …
neuromodulation. DBS is a standard of care in Parkinson disease, essential tremor and …
Adaptive deep brain stimulation: From experimental evidence toward practical implementation
WJ Neumann, R Gilron, S Little… - Movement …, 2023 - Wiley Online Library
Closed‐loop adaptive deep brain stimulation (aDBS) can deliver individualized therapy at
an unprecedented temporal precision for neurological disorders. This has the potential to …
an unprecedented temporal precision for neurological disorders. This has the potential to …
Long-term wireless streaming of neural recordings for circuit discovery and adaptive stimulation in individuals with Parkinson's disease
Neural recordings using invasive devices in humans can elucidate the circuits underlying
brain disorders, but have so far been limited to short recordings from externalized brain …
brain disorders, but have so far been limited to short recordings from externalized brain …
Chronic adaptive deep brain stimulation versus conventional stimulation in Parkinson's disease: a blinded randomized feasibility trial
Deep brain stimulation (DBS) is a widely used therapy for Parkinson's disease (PD) but
lacks dynamic responsiveness to changing clinical and neural states. Feedback control …
lacks dynamic responsiveness to changing clinical and neural states. Feedback control …
Deep brain stimulation in movement disorders: from experimental surgery to evidence‐based therapy
Deep brain stimulation (DBS) of 3 different targets is the most important therapeutic
innovation of the past 30 years for patients with fluctuating Parkinson's disease (PD) …
innovation of the past 30 years for patients with fluctuating Parkinson's disease (PD) …
[HTML][HTML] Spectral and spatial distribution of subthalamic beta peak activity in Parkinson's disease patients
Current efforts to optimise subthalamic deep brain stimulation in Parkinson's disease
patients aim to harness local oscillatory activity in the beta frequency range (13–35 Hz) as a …
patients aim to harness local oscillatory activity in the beta frequency range (13–35 Hz) as a …
[HTML][HTML] Local field potentials in Parkinson's disease: a frequency-based review
Deep brain stimulation (DBS) surgery offers a unique opportunity to record local field
potentials (LFPs), the electrophysiological population activity of neurons surrounding the …
potentials (LFPs), the electrophysiological population activity of neurons surrounding the …
[HTML][HTML] The pathophysiology of Parkinson's disease tremor
Tremor is one of the primary motor symptoms of Parkinson's disease (PD), and it is
characterized by a highly phenomenological heterogeneity. Clinical and experimental …
characterized by a highly phenomenological heterogeneity. Clinical and experimental …
Freezing of gait: understanding the complexity of an enigmatic phenomenon
Diverse but complementary methodologies are required to uncover the complex
determinants and pathophysiology of freezing of gait. To develop future therapeutic …
determinants and pathophysiology of freezing of gait. To develop future therapeutic …
Debugging adaptive deep brain stimulation for Parkinson's disease
Deep brain stimulation (DBS) is a successful treatment for patients with Parkinson's disease.
In adaptive DBS, stimulation is titrated according to feedback about clinical state and …
In adaptive DBS, stimulation is titrated according to feedback about clinical state and …