Patterns of gene expression, splicing, and Allele-specific expression vary among macular tissues and clinical stages of age-related macular degeneration
Age-related macular degeneration (AMD) is a leading cause of blindness, and elucidating
its underlying disease mechanisms is vital to the development of appropriate therapeutics …
its underlying disease mechanisms is vital to the development of appropriate therapeutics …
[HTML][HTML] Eye in a disk: eyeIntegration human pan-eye and body transcriptome database version 1.0
V Swamy, D McGaughey - Investigative ophthalmology & visual …, 2019 - tvst.arvojournals.org
Purpose: We develop an accessible and reliable RNA sequencing (RNA-seq) transcriptome
database of healthy human eye tissues and a matching reactive web application to query …
database of healthy human eye tissues and a matching reactive web application to query …
RNA-sequencing in ophthalmology research: considerations for experimental design and analysis
N Owen, M Moosajee - Therapeutic Advances in …, 2019 - journals.sagepub.com
High-throughput, massively parallel sequence analysis has revolutionized the way that
researchers design and execute scientific investigations. Vast amounts of sequence data …
researchers design and execute scientific investigations. Vast amounts of sequence data …
Exploring the lncRNA localization landscape within the retinal pigment epithelium under normal and stress conditions
TJ Kaczynski, ED Au, MH Farkas - BMC genomics, 2022 - Springer
Abstract Background Long noncoding RNAs (lncRNAs) are emerging as a class of genes
whose importance has yet to be fully realized. It is becoming clear that the primary function …
whose importance has yet to be fully realized. It is becoming clear that the primary function …
Patterns of gene expression and allele-specific expression vary among macular tissues and clinical stages of Age-related Macular Degeneration
Age-related macular degeneration (AMD) is a complex neurodegenerative disease and is
the leading cause of blindness in the aging population. Early AMD is characterized by …
the leading cause of blindness in the aging population. Early AMD is characterized by …
Volatile evolution of long non-coding RNA repertoire in retinal pigment epithelium: insights from comparison of bovine and human RNA expression profiles
OA Postnikova, IB Rogozin, W Samuel, G Nudelman… - Genes, 2019 - mdpi.com
Currently, several long non-coding RNAs (lncRNAs)(TUG1, MALAT1, MEG3 and others)
have been discovered to regulate normal visual function and may potentially contribute to …
have been discovered to regulate normal visual function and may potentially contribute to …
[HTML][HTML] Morphological, biochemical, and transcriptomic characterization of iPSC-derived human RPE cells from normal and Smith-Lemli-Opitz syndrome patients
MH Farkas, LA Skelton, S Ramachandra-Rao… - Molecular …, 2022 - ncbi.nlm.nih.gov
Purpose: Smith-Lemli-Opitz syndrome (SLOS) is a human recessive disease that affects
cellular cholesterol (Chol) synthesis due to mutations in the gene encoding 7 …
cellular cholesterol (Chol) synthesis due to mutations in the gene encoding 7 …
RNA sequencing and transcriptome analysis
ED Au, MH Farkas - Genetics and Genomics of Eye Disease, 2020 - Elsevier
RNA sequencing (RNA-Seq) studies have become the gold standard for high-throughput
transcriptome analysis. The amount of data produced by RNA-Seq is unparalleled, providing …
transcriptome analysis. The amount of data produced by RNA-Seq is unparalleled, providing …
[PDF][PDF] Patterns of Gene Expression, Splicing, and Allele-Specific Expression Vary among Macular Tissues and Clinical Stages of Age-Related Macular Degeneration …
Age-related macular degeneration (AMD) is a leading cause of blindness, and elucidating
its underlying disease mechanisms is vital to the development of appropriate therapeutics …
its underlying disease mechanisms is vital to the development of appropriate therapeutics …
[HTML][HTML] Oxidative stress alters transcript localization of disease-associated genes in the retinal pigment epithelium
TJ Kaczynski, ED Au, MH Farkas - Molecular Vision, 2022 - ncbi.nlm.nih.gov
Purpose Nuclear retention is a mechanism whereby excess RNA transcripts are stored in
the event that a cell needs to quickly respond to a stimulus; maintaining proper nuclear-to …
the event that a cell needs to quickly respond to a stimulus; maintaining proper nuclear-to …