Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment

RA McCutcheon, RSE Keefe, PK McGuire - Molecular psychiatry, 2023 - nature.com
Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …

The impact of the human thalamus on brain-wide information processing

JM Shine, LD Lewis, DD Garrett… - Nature Reviews …, 2023 - nature.com
The thalamus is a small, bilateral structure in the diencephalon that integrates signals from
many areas of the CNS. This critical anatomical position allows the thalamus to influence …

Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer's disease pathology

H Mathys, Z Peng, CA Boix, MB Victor, N Leary, S Babu… - Cell, 2023 - cell.com
Alzheimer's disease (AD) is the most common cause of dementia worldwide, but the
molecular and cellular mechanisms underlying cognitive impairment remain poorly …

Schizophrenia—an overview

RA McCutcheon, TR Marques, OD Howes - JAMA psychiatry, 2020 - jamanetwork.com
Importance Schizophrenia is a common, severe mental illness that most clinicians will
encounter regularly during their practice. This report provides an overview of the clinical …

Electrochemical‐Memristor‐Based Artificial Neurons and Synapses—Fundamentals, Applications, and Challenges

S Chen, T Zhang, S Tappertzhofen, Y Yang… - Advanced …, 2023 - Wiley Online Library
Artificial neurons and synapses are considered essential for the progress of the future brain‐
inspired computing, based on beyond von Neumann architectures. Here, a discussion on …

[HTML][HTML] A transcriptomic axis predicts state modulation of cortical interneurons

S Bugeon, J Duffield, M Dipoppa, A Ritoux, I Prankerd… - Nature, 2022 - nature.com
Transcriptomics has revealed that cortical inhibitory neurons exhibit a great diversity of fine
molecular subtypes,,,,–, but it is not known whether these subtypes have correspondingly …

Over and above frequency: Gamma oscillations as units of neural circuit operations

A Fernandez-Ruiz, A Sirota, V Lopes-dos-Santos… - Neuron, 2023 - cell.com
Summary Gamma oscillations (∼ 30–150 Hz) are widespread correlates of neural circuit
functions. These network activity patterns have been described across multiple animal …

[HTML][HTML] Where is the error? Hierarchical predictive coding through dendritic error computation

FA Mikulasch, L Rudelt, M Wibral… - Trends in Neurosciences, 2023 - cell.com
Top-down feedback in cortex is critical for guiding sensory processing, which has
prominently been formalized in the theory of hierarchical predictive coding (hPC). However …

Adolescence as a neurobiological critical period for the development of higher-order cognition

B Larsen, B Luna - Neuroscience & Biobehavioral Reviews, 2018 - Elsevier
The transition from adolescence to adulthood is characterized by improvements in higher-
order cognitive abilities and corresponding refinements of the structure and function of the …

[HTML][HTML] Multi-sensory gamma stimulation ameliorates Alzheimer's-associated pathology and improves cognition

AJ Martorell, AL Paulson, HJ Suk, F Abdurrob… - Cell, 2019 - cell.com
We previously reported that inducing gamma oscillations with a non-invasive light flicker
(gamma entrainment using sensory stimulus or GENUS) impacted pathology in the visual …