Physical activity as the best supportive care in cancer: the clinician's and the researcher's perspectives

C Torregrosa, F Chorin, EEM Beltran, C Neuzillet… - Cancers, 2022 - mdpi.com
Simple Summary This literature review on adapted physical exercise has been written in
order to raise awareness of medical staff to this central theme in the management of cancer …

Altered Ca2+ Handling and Oxidative Stress Underlie Mitochondrial Damage and Skeletal Muscle Dysfunction in Aging and Disease

A Michelucci, C Liang, F Protasi, RT Dirksen - Metabolites, 2021 - mdpi.com
Skeletal muscle contraction relies on both high-fidelity calcium (Ca2+) signals and robust
capacity for adenosine triphosphate (ATP) generation. Ca2+ release units (CRUs) are highly …

An Orai1 gain-of-function tubular aggregate myopathy mouse model phenocopies key features of the human disease

N Zhao, A Michelucci, L Pietrangelo, S Malik… - The EMBO …, 2024 - embopress.org
Tubular aggregate myopathy (TAM) is a heritable myopathy primarily characterized by
progressive muscle weakness, elevated levels of creatine kinase (CK), hypocalcemia …

Excitation-contraction coupling in mammalian skeletal muscle: Blending old and last-decade research

P Bolaños, JC Calderón - Frontiers in Physiology, 2022 - frontiersin.org
The excitation–contraction coupling (ECC) in skeletal muscle refers to the Ca2+-mediated
link between the membrane excitation and the mechanical contraction. The initiation and …

Long-Term Exercise Reduces Formation of Tubular Aggregates and Promotes Maintenance of Ca2+ Entry Units in Aged Muscle

S Boncompagni, C Pecorai, A Michelucci… - Frontiers in …, 2021 - frontiersin.org
Tubular aggregates (TAs) in skeletal muscle fibers are unusual accumulation of
sarcoplasmic reticulum (SR) tubes that are found in different disorders including TA …

Calcium entry units (CEUs): Perspectives in skeletal muscle function and disease

F Protasi, L Pietrangelo, S Boncompagni - Journal of Muscle Research …, 2021 - Springer
In the last decades the term Store-operated Ca 2+ entry (SOCE) has been used in the
scientific literature to describe an ubiquitous cellular mechanism that allows recovery of …

Pre-assembled Ca2+ entry units and constitutively active Ca2+ entry in skeletal muscle of calsequestrin-1 knockout mice

A Michelucci, S Boncompagni, L Pietrangelo… - Journal of General …, 2020 - rupress.org
Store-operated Ca2+ entry (SOCE) is a ubiquitous Ca2+ influx mechanism triggered by
depletion of Ca2+ stores from the endoplasmic/sarcoplasmic reticulum (ER/SR). We recently …

Store-operated calcium entry: From physiology to tubular aggregate myopathy

F Protasi, B Girolami, S Roccabianca… - Current Opinion in …, 2023 - Elsevier
Abstract Store-Operated Ca 2+ entry (SOCE) is recognized as a key mechanism in muscle
physiology necessary to refill intracellular Ca 2+ stores during sustained muscle activity. For …

Calsequestrin, a key protein in striated muscle health and disease

D Rossi, A Gamberucci, E Pierantozzi, C Amato… - Journal of Muscle …, 2021 - Springer
Calsequestrin (CASQ) is the most abundant Ca 2+ binding protein localized in the
sarcoplasmic reticulum (SR) of skeletal and cardiac muscle. The genome of vertebrates …

Postdevelopmental knockout of Orai1 improves muscle pathology in a mouse model of Duchenne muscular dystrophy

M García-Castañeda, A Michelucci, N Zhao… - Journal of General …, 2022 - rupress.org
Duchenne muscular dystrophy (DMD), an X-linked disorder caused by loss-of-function
mutations in the dystrophin gene, is characterized by progressive muscle degeneration and …