The importance and role of the estrogen receptor (ER) pathway has been well-documented
in both breast cancer (BC) development and progression. The treatment of choice in women …

Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor
signalling. However, recent reports indicate that SYK also mediates other, unexpectedly …

Protein phosphorylation controls many cellular processes, especially those involved in
intercellular communication and coordination of complex functions. To explore the evolution …

Alternative splicing of mRNA precursors enables one gene to produce multiple protein
isoforms with differing functions. Under normal conditions, this mechanism is tightly …

Although it is well established that reactive oxygen intermediates mediate the NF-κB
activation induced by most agents, how H 2 O 2 activates this transcription factor is not well …

The Src, Syk, and Tec family kinases are three of the most well characterized tyrosine kinase
families found in the human genome. Members of these kinase families function …

The Syk tyrosine kinase plays a critical role in the signaling machinery of various receptors
of the adaptive immune system. Here we show that Syk is also an essential component of …

Abstract Knowledge about breast carcinogenesis has accumulated during the last decades
but has barely been translated into strategies for early detection or prevention of this …

Spleen tyrosine kinase (Syk) is a cytoplasmic protein tyrosine kinase well known for its
ability to couple immune cell receptors to intracellular signaling pathways that regulate …

Stilbenes are small molecular weight (∼ 200-300 g/mol), naturally occurring compounds
and are found in a wide range of plant sources, aromatherapy products, and dietary …