Inter-tissue communication in cancer cachexia

JM Argilés, B Stemmler, FJ López-Soriano… - Nature Reviews …, 2019 - nature.com
Cachexia is a systemic condition that occurs during many neoplastic diseases, such as
cancer. Cachexia in cancer is characterized by loss of body weight and muscle and by …

Physical activity-dependent regulation of parathyroid hormone and calcium-phosphorous metabolism

G Lombardi, E Ziemann, G Banfi… - International journal of …, 2020 - mdpi.com
Exercise perturbs homeostasis, alters the levels of circulating mediators and hormones, and
increases the demand by skeletal muscles and other vital organs for energy substrates …

SERCA2a: a key protein in the Ca2+ cycle of the heart failure

L Zhihao, N Jingyu, L Lan, S Michael, G Rui, B Xiyun… - Heart failure …, 2020 - Springer
Abstract Calcium ion (Ca 2+) cycle plays a crucial role in the contraction and relaxation of
cardiomyocytes. The sarcoplasmic reticulum (SR) acts as an organelle for storing Ca 2+ …

MCUB regulates the molecular composition of the mitochondrial calcium uniporter channel to limit mitochondrial calcium overload during stress

JP Lambert, TS Luongo, D Tomar, P Jadiya, E Gao… - Circulation, 2019 - Am Heart Assoc
Background: The mitochondrial calcium uniporter (mtCU) is an≈ 700-kD multisubunit
channel residing in the inner mitochondrial membrane required for mitochondrial Ca2+ …

Endogenous and exogenous antioxidants in skeletal muscle fatigue development during exercise

E Supruniuk, J Górski, A Chabowski - Antioxidants, 2023 - mdpi.com
Muscle fatigue is defined as a decrease in maximal force or power generated in response to
contractile activity, and it is a risk factor for the development of musculoskeletal injuries. One …

Mice with myocyte deletion of vitamin D receptor have sarcopenia and impaired muscle function

CM Girgis, KM Cha, B So, M Tsang… - Journal of cachexia …, 2019 - Wiley Online Library
Background It has long been recognized that vitamin D deficiency is associated with muscle
weakness and falls. Vitamin D receptor (VDR) is present at very low levels in normal muscle …

A review of pharmacological and pharmacokinetic properties of stachydrine

F Cheng, Y Zhou, M Wang, C Guo, Z Cao… - Pharmacological …, 2020 - Elsevier
Stachydrine is extracted from the leaves of Leonurus japonicus Houtt (or Motherwort,“Yi Mu
Cao” in Traditional Chinese Medicine) and is the major bioactive ingredient. So far …

Targeting calcium homeostasis in myocardial ischemia/reperfusion injury: an overview of regulatory mechanisms and therapeutic reagents

R Wang, M Wang, S He, G Sun, X Sun - Frontiers in pharmacology, 2020 - frontiersin.org
Calcium homeostasis plays an essential role in maintaining excitation–contraction coupling
(ECC) in cardiomyocytes, including calcium release, recapture, and storage. Disruption of …

TECRL, a new life‐threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT

HD Devalla, R Gélinas, EH Aburawi… - EMBO molecular …, 2016 - embopress.org
Genetic causes of many familial arrhythmia syndromes remain elusive. In this study, whole‐
exome sequencing (WES) was carried out on patients from three different families that …

An unbiased proteomics method to assess the maturation of human pluripotent stem cell–derived cardiomyocytes

W Cai, J Zhang, WJ de Lange, ZR Gregorich… - Circulation …, 2019 - Am Heart Assoc
Rationale: Human pluripotent stem cell (hPSC)–derived cardiomyocytes exhibit the
properties of fetal cardiomyocytes, which limits their applications. Various methods have …