CAR‐NK cell in cancer immunotherapy; A promising frontier
Chimeric antigen receptors (CARs) have a unique facet of synthetic biology and offer a
paradigm shift in personalized medicine as they can use and redirect the patient's immune …
paradigm shift in personalized medicine as they can use and redirect the patient's immune …
NKG2D: a master regulator of immune cell responsiveness
NKG2D is an activating receptor that is mostly expressed on cells of the cytotoxic arm of the
immune system. Ligands of NKG2D are normally of low abundance, but can be induced in …
immune system. Ligands of NKG2D are normally of low abundance, but can be induced in …
NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis
Metabolic-associated fatty liver disease (MAFLD) is a spectrum of clinical manifestations
ranging from benign steatosis to cirrhosis. A key event in the pathophysiology of MAFLD is …
ranging from benign steatosis to cirrhosis. A key event in the pathophysiology of MAFLD is …
[HTML][HTML] The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation
Natural killer (NK) cells play critical roles defending against tumors and pathogens. We
show that mice lacking both transcription factors Eomesodermin (Eomes) and T-bet failed to …
show that mice lacking both transcription factors Eomesodermin (Eomes) and T-bet failed to …
Innate lymphoid cells control signaling circuits to regulate tissue-specific immunity
CSN Klose, D Artis - Cell research, 2020 - nature.com
The multifaceted organization of the immune system involves not only patrolling
lymphocytes that constantly monitor antigen-presenting cells in secondary lymphoid organs …
lymphocytes that constantly monitor antigen-presenting cells in secondary lymphoid organs …
Natural killer cells act as rheostats modulating antiviral T cells
Antiviral T cells are thought to regulate whether hepatitis C virus (HCV) and human
immunodeficiency virus (HIV) infections result in viral control, asymptomatic persistence or …
immunodeficiency virus (HIV) infections result in viral control, asymptomatic persistence or …
Location and cellular stages of natural killer cell development
The identification of distinct tissue-specific natural killer (NK) cell populations that apparently
mature from local precursor populations has brought new insight into the diversity and …
mature from local precursor populations has brought new insight into the diversity and …
[HTML][HTML] NKG2D ligands mediate immunosurveillance of senescent cells
A Sagiv, DGA Burton, Z Moshayev, E Vadai… - Aging (Albany …, 2016 - ncbi.nlm.nih.gov
Cellular senescence is a stress response mechanism that limits tumorigenesis and tissue
damage. Induction of cellular senescence commonly coincides with an immunogenic …
damage. Induction of cellular senescence commonly coincides with an immunogenic …
Effect of NKG2D ligand expression on host immune responses
M Champsaur, LL Lanier - Immunological reviews, 2010 - Wiley Online Library
Natural killer group 2, member D (NKG2D) is an activating receptor present on the surface of
natural killer (NK) cells, some NKT cells, CD8+ cytotoxic T cells, γδ T cells, and under certain …
natural killer (NK) cells, some NKT cells, CD8+ cytotoxic T cells, γδ T cells, and under certain …
γδ T cells and the lymphoid stress-surveillance response
AC Hayday - Immunity, 2009 - cell.com
The investigation of γδ T cells has identified a rapid lymphoid stress-surveillance response
to microbial and nonmicrobial tissue perturbation. In addition to providing local protection …
to microbial and nonmicrobial tissue perturbation. In addition to providing local protection …