Introduction Long term complications of COVID-19, the disease caused by the SARS-CoV-2,
involve many organ systems, dramatically worsening the quality of life, and finally …

Nitric oxide/cyclic guanosine monophosphate (cGMP) signaling is compromised in
Alzheimer's disease (AD), and phosphodiesterase 5 (PDE5), which degrades cGMP, is …

Highlights•Tadalafil mitigated cisplatin-induced testicular toxicity in male rats.•Tadalafil
antagonized cisplatin-induced oxidative stress and inflammatory markers.•Tadalafil acts by …

Introduction The recent global outbreak of coronavirus disease 2019 (COVID-19) has
become a pandemic with a lot of sufferers. Excessive inflammation, exaggerated immune …

Introduction Despite the ever-increasing occurrences of the coronavirus disease (COVID-19)
cases around the world, very few medications have been validated in the clinical trials to …

Non-steroidal anti-inflammatory drugs (NSAIDs)-induced gastric ulcers represent a
significant clinical concern and adversely affect the quality of life. Inducible nitric oxide …

Importance to the field: Since sildenafil was introduced 10 years ago, highly selective
phosphodiesterase type 5 inhibitors (PDE5i) have changed the medical management of …

BACKGROUND/PURPOSE: The aim of the study was to evaluate the effects of tadalafil
(TDF) on ischemia/reperfusion (I/R) injury in rat ovaries. METHODS: Thirty-five female …

Sildenafil Citrate (SC) is a US FDA approved drug, have been used to treat wounds due to
their nitric oxide (NO) stimulating activity in the tissue. But, there are only a few studies about …

Heat-stable toxins (STs) produced by enterotoxigenic bacteria cause endemic and traveler's
diarrhea by binding to and activating the intestinal receptor guanylyl cyclase C (GC-C) …