G-Quadruplexes are non-B form DNA structures present at regulatory regions in the
genome, such as promoters of proto-oncogenes and telomeres. The prominence in such …

Telomere shortening occurs during oxidative and inflammatory stress with guanine (G) as
the major site of damage. In this work, a comprehensive profile of the sites of oxidation and …

A quadruplex sequence from the promoter region of the c-KIT gene forms a stable
quadruplex, as characterized by crystallographic and NMR methods. Two new crystal …

The human telomeric DNA sequence with four repeats can fold into a parallel-stranded
propeller-type topology. NMR structures solved under molecular crowding experiments …

Abstract G-quadruplexes (G4) are highly stable tetra-stranded secondary DNA structures
known to mediate gene regulation. These structures are resolved by DNA helicases and are …

The review presents currently available data on the biological role of 8-oxo-2'-
deoxyguanosine. This compound for a long time has been used successfully as a biomarker …

The most popular biomarker of cellular senescence (BCS) is the activity of senescence-
associated β-galactosidase (SA-β-Gal). Today, this is the prevailing BCS in the studies …

Ionizing radiation produces clustered damage to DNA which is difficult to repair and thus
more harmful than single lesions. Clustered lesions have only been investigated in dsDNA …

As part of the genome, human telomeric regions can be damaged by the chemically reactive
molecules responsible for oxidative DNA damage. Considering that G-quadruplex structures …

In the last two decades, the design of new drugs able to selectively recognize noncanonical
structures at the promoter of oncogenes has received much attention as potential anticancer …