While century old clinical reports document the periosteum's remarkable regenerative
capacity, only in the past decade have scientists undertaken mechanistic investigations of its …

Extracellular vesicles (EVs) are small membrane vesicles that can be secreted by most cells.
EVs can be released into the extracellular environment through exocytosis, transporting …

Mesenchymal stem cell-derived exosomes (MSC-exos), with its inherent capacity to
modulate cellular behavior, are emerging as a novel cell-free therapy for bone regeneration …

The osteoimmunomodulatory property of bone biomaterials is a vital property determining
the in vivo fate of the implants. Endowing bone biomaterials with favorable …

Crosstalk between nerves and bone is essential for bone repair, for which Schwann cells
(SCs) are crucial in the regulation of the microenvironment. Considering that exosomes are …

In the process of bone tissue engineering, the osteoimmunomodulatory property of
biomaterials is very important for osteogenic differentiation of stem cells, which determines …

The bone-regenerative potentials of the periosteum have been explored as early as the 17th
century. Over the past few years, however, much has been discovered in terms of the …

Bone defects caused by trauma, infection and congenital diseases still face great
challenges. Dihydromyricetin (DHM) is a kind of flavone extracted from Ampelopsis …

Vascular calcification (VC) is associated with cardiovascular disease. Baicalein, a natural
flavonoid extract of Scutellaria baicalensis rhizome has several biological properties which …

Background Piezosurgery is an osteotomy system used in medical and dental surgery.
Manystudies have proven clinical advantages of piezosurgery in terms of quality ofcut …