DNA mutations are inevitable. Despite proficient DNA repair mechanisms, somatic cells
accumulate mutations during development and aging, generating cells with different …

Cancer is an age-related disease, as incidence and mortality for most types of cancer
increase with age. However, how molecular alterations in tumors differ among patients of …

Pan-cancer analyses that examine commonalities and differences among various cancer
types have emerged as a powerful way to obtain novel insights into cancer biology. Here we …

Many primary-tumor subregions have low levels of molecular oxygen, termed hypoxia.
Hypoxic tumors are at elevated risk for local failure and distant metastasis, but the molecular …

The gradual accumulation of genetic mutations in human adult stem cells (ASCs) during life
is associated with various age-related diseases, including cancer,. Extreme variation in …

The germline mutation rate has been extensively studied and has been found to vary greatly
between species, but much less is known about the somatic mutation rate in multicellular …

For many cancer types, incidence rises rapidly with age as an apparent power law,
supporting the idea that cancer is caused by a gradual accumulation of genetic mutations …

Age is the most important risk factor for cancer, as cancer incidence and mortality increase
with age. However, how molecular alterations in tumours differ among patients of different …

The role of brain somatic mutations in Alzheimer's disease (AD) is not well understood.
Here, we perform deep whole-exome sequencing (average read depth 584×) in 111 …

γH2AX has emerged in the last 20 years as a central player in the DDR (DNA damage
response), with specificity for DSBs (double-strand breaks). Upon the generation of DSBs, γ …