Necrotizing enterocolitis: new insights into pathogenesis and mechanisms

DF Niño, CP Sodhi, DJ Hackam - Nature reviews Gastroenterology & …, 2016 - nature.com
Necrotizing enterocolitis (NEC) is the most frequent and lethal disease of the gastrointestinal
tract of preterm infants. At present, NEC is thought to develop in the premature host in the …

Can probiotics modulate human disease by impacting intestinal barrier function?

PA Bron, M Kleerebezem, RJ Brummer… - British Journal of …, 2017 - cambridge.org
Intestinal barrier integrity is a prerequisite for homeostasis of mucosal function, which is
balanced to maximise absorptive capacity, while maintaining efficient defensive reactions …

Exosome-derived microRNAs of human milk and their effects on infant health and development

BC Melnik, W Stremmel, R Weiskirchen, SM John… - Biomolecules, 2021 - mdpi.com
Multiple biologically active components of human milk support infant growth, health and
development. Milk provides a wide spectrum of mammary epithelial cell-derived …

Rapid MinION profiling of preterm microbiota and antimicrobial-resistant pathogens

RM Leggett, C Alcon-Giner, D Heavens, S Caim… - Nature …, 2020 - nature.com
The MinION sequencing platform offers near real-time analysis of DNA sequence; this
makes the tool attractive for deployment in fieldwork or clinical settings. We used the MinION …

Antibiotic exposure in the newborn intensive care unit and the risk of necrotizing enterocolitis

VN Alexander, V Northrup, MJ Bizzarro - The Journal of pediatrics, 2011 - Elsevier
OBJECTIVE: To determine whether duration of antibiotic exposure is an independent risk
factor for necrotizing enterocolitis (NEC). STUDY DESIGN: A retrospective, 2: 1 control-case …

The human milk oligosaccharide 2′-fucosyllactose attenuates the severity of experimental necrotising enterocolitis by enhancing mesenteric perfusion in the …

M Good, CP Sodhi, Y Yamaguchi, H Jia, P Lu… - British journal of …, 2016 - cambridge.org
Necrotising enterocolitis (NEC) is a common disease in premature infants characterised by
intestinal ischaemia and necrosis. The only effective preventative strategy against NEC is …

Protective effects of bifidobacterium on intestinal barrier function in LPS-induced enterocyte barrier injury of Caco-2 monolayers and in a rat NEC model

X Ling, P Linglong, D Weixia, W Hong - PloS one, 2016 - journals.plos.org
Zonulin protein is a newly discovered modulator which modulates the permeability of the
intestinal epithelial barrier by disassembling intercellular tight junctions (TJ). Disruption of TJ …

A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair

CL Leaphart, J Cavallo, SC Gribar, S Cetin… - The journal of …, 2007 - journals.aai.org
Necrotizing enterocolitis (NEC) is the leading cause of death from gastrointestinal disease in
preterm infants and is characterized by translocation of LPS across the inflamed intestine …

Necrotizing enterocolitis: an update

L Berman, RL Moss - Seminars in fetal and neonatal medicine, 2011 - Elsevier
Necrotizing enterocolitis (NEC) is a leading cause of death among patients in the neonatal
intensive care unit, carrying a mortality rate of 15–30%. Its pathogenesis is multifactorial and …

Necrotizing enterocolitis in newborns: pathogenesis, prevention and management

AM Thompson, MJ Bizzarro - Drugs, 2008 - Springer
Necrotizing enterocolitis (NEC) is primarily a disease process of the gastrointestinal (GI) tract
of premature neonates that results in inflammation and bacterial invasion of the bowel wall …