Role of myeloperoxidase in inflammation and atherosclerosis

C Frangie, J Daher - Biomedical reports, 2022 - spandidos-publications.com
Myeloperoxidase (MPO) belongs to the heme peroxidase family, which includes a set of
enzymes with potent oxidoreductase activity. MPO is considered an important part of the …

Unexpected role of MPO-oxidized LDLs in atherosclerosis: In between inflammation and its resolution

C Tangeten, K Zouaoui Boudjeltia, C Delporte… - Antioxidants, 2022 - mdpi.com
Inflammation and its resolution are the result of the balance between pro-inflammatory and
pro-resolving factors, such as specialized pro-resolving mediators (SPMs). This balance is …

Oxidized LDL-regulated microRNAs for evaluating vascular endothelial function: molecular mechanisms and potential biomarker roles in atherosclerosis

A Kianmehr, D Qujeq, A Bagheri… - Critical Reviews in …, 2022 - Taylor & Francis
As a simple monolayer, vascular endothelial cells can respond to physicochemical stimuli. In
addition to promoting the formation of foam cells, oxidized low-density lipoprotein (ox-LDL) …

The role of exosomes and exosome-derived microRNAs in atherosclerosis

X Lu - Current pharmaceutical design, 2017 - ingentaconnect.com
Background: Atherosclerosis is the leading cause of death and morbidity throughout
industrialized nations, accounting for one-fifth of all deaths globally. Exosomes are bi-lipid …

The lipid paradox in neuroprogressive disorders: causes and consequences

G Morris, M Berk, K Walder, A O'Neil, M Maes… - Neuroscience & …, 2021 - Elsevier
Chronic systemic inflammation is associated with an increased risk of cardiovascular
disease in an environment of low low-density lipoprotein (LDL) and low total cholesterol and …

Binding of lactoferrin to the surface of low-density lipoproteins modified by myeloperoxidase prevents intracellular cholesterol accumulation by human blood …

VB Vasilyev, AV Sokolov, VA Kostevich… - … and Cell Biology, 2021 - cdnsciencepub.com
Myeloperoxidase (MPO) is a unique heme-containing peroxidase that can catalyze the
formation of hypochlorous acid (HOCl). The strong interaction of MPO with low-density …

MiR-22 promotes porcine reproductive and respiratory syndrome virus replication by targeting the host factor HO-1

S Xiao, T Du, X Wang, H Ni, Y Yan, N Li, C Zhang… - Veterinary …, 2016 - Elsevier
Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most
economically important viruses affecting the swine industry worldwide. MicroRNAs …

[HTML][HTML] A Potential Link between Myeloperoxidase Modified LDL, Atherosclerosis and Depression

J Daher - International Journal of Molecular Sciences, 2024 - mdpi.com
Atherosclerosis is a chronic inflammatory disease that involves modified low-density
lipoproteins (LDL) which play a pivotal role in the initiation and progression of the disease …

Apoliporotein L3 interferes with endothelial tube formation via regulation of ERK1/2, FAK and Akt signaling pathway

A Khalil, P Poelvoorde, M Fayyad-Kazan, A Rousseau… - Atherosclerosis, 2018 - Elsevier
Background and aims Endothelial cells are main actors in vascular homeostasis as they
regulate vascular pressure and permeability as well as hemostasis and inflammation …

Myeloperoxidase-oxidized LDL activates human aortic endothelial cells through the LOX-1 scavenger receptor

L El-Hajjar, J Hindieh, R Andraos, M El-Sabban… - International journal of …, 2022 - mdpi.com
Cardiovascular disease as a result of atherosclerosis is a leading cause of death worldwide.
Atherosclerosis is primarily caused by the dysfunction of vascular endothelial cells and the …