Intrauterine programming of obesity and type 2 diabetes
The type 2 diabetes epidemic and one of its predisposing factors, obesity, are major
influences on global health and economic burden. It is accepted that genetics and the …
influences on global health and economic burden. It is accepted that genetics and the …
Smoking and pregnancy: Epigenetics and developmental origins of the metabolic syndrome
JM Rogers - Birth defects research, 2019 - Wiley Online Library
Maternal smoking causes lower birth weight, birth defects, and other adverse pregnancy
outcomes. Epidemiological evidence over the past four decades has grown stronger and the …
outcomes. Epidemiological evidence over the past four decades has grown stronger and the …
DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis
Epigenetic modifications, including DNA methylation, represent a potential mechanism for
environmental impacts on human disease. Maternal smoking in pregnancy remains an …
environmental impacts on human disease. Maternal smoking in pregnancy remains an …
DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood
Although it is assumed that epigenetic mechanisms, such as changes in DNA methylation
(DNAm), underlie the relationship between adverse intrauterine conditions and adult …
(DNAm), underlie the relationship between adverse intrauterine conditions and adult …
Data resource profile: accessible resource for integrated epigenomic studies (ARIES)
ARIES is a population-based resource of DNA methylation data accessible by the research
community, established with the aim of improving our understanding of the determinants and …
community, established with the aim of improving our understanding of the determinants and …
Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
Birthweight is associated with health outcomes across the life course, DNA methylation may
be an underlying mechanism. In this meta-analysis of epigenome-wide association studies …
be an underlying mechanism. In this meta-analysis of epigenome-wide association studies …
Cohort profile: pregnancy and childhood epigenetics (PACE) consortium
JF Felix, BR Joubert, AA Baccarelli… - International journal …, 2018 - academic.oup.com
Epigenetics refers to mitotically heritable changes to the DNA, which do not affect the DNA
sequence, but can influence its function. Currently, DNA methylation is the most studied …
sequence, but can influence its function. Currently, DNA methylation is the most studied …
Epigenetic regulation in development: is the mouse a good model for the human?
BACKGROUND Over the past few years, advances in molecular technologies have allowed
unprecedented mapping of epigenetic modifications in gametes and during early embryonic …
unprecedented mapping of epigenetic modifications in gametes and during early embryonic …
Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health
Background Tobacco smoking is a risk factor for multiple diseases, including cardiovascular
disease and diabetes. Many smoking-associated signals have been detected in the blood …
disease and diabetes. Many smoking-associated signals have been detected in the blood …
DNA methylation: a potential mediator between air pollution and metabolic syndrome
Given the global increase in air pollution and its crucial role in human health, as well as the
steep rise in prevalence of metabolic syndrome (MetS), a better understanding of the …
steep rise in prevalence of metabolic syndrome (MetS), a better understanding of the …