Fibrosis, or tissue scarring, develops as a pathological deviation from the physiological
wound healing response and can occur in various organs such as the heart, lung, liver …

Pirfenidone (PFD) is a non-peptide synthetic chemical that inhibits the production of
transforming growth factor-beta 1 (TGF-β1), tumor necrosis factor-alpha (TNF-α), platelet …

Protein S-glutathionylation is emerging as a central oxidation that regulates redox signaling
and biological processes linked to diseases. In recent years, the field of protein S …

Activation of hepatic stellate cells (HSCs) plays a critical role in liver fibrosis. However, the
molecular basis for HSC activation remains poorly understood. Herein, we demonstrate that …

The vasculature occupies a large area of the body, and none of the physiological activities
can be carried out without blood vessels. Blood vessels are not just passive conduits and …

Background Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic disease
characterised by aberrant fibroblast/myofibroblast accumulation and excessive collagen …

Liver cirrhosis is the end‐stage of chronic liver disease, characterized by inflammation,
necrosis, advanced fibrosis, and regenerative nodule formation. Long‐term inflammation …

Activation of extracellular matrix–producing hepatic stellate cells (HSCs) is a key event in
liver fibrogenesis. We showed that the expression of the heme-thiolate monooxygenase …

Rationale Chronic liver fibrosis is a common and irreversible disease in clinical practice, and
Pirfenidone (PFD) has been shown to effectively inhibit the progression of liver fibrosis in …

Background Liver fibrosis (LF) is a trauma repair process carried out by the liver in response
to various acute and chronic liver injuries. Its primary pathological characteristics are …