Malaria has been a major global health problem of humans through history and is a leading
cause of death and disease across many tropical and subtropical countries. Over the last …

Cerebral malaria is among the major causes of malaria-associated mortality and effective
adjunctive therapeutic strategies are currently lacking. Central pathophysiological processes …

Malaria remains a major cause of morbidity and mortality in the tropics, with Plasmodium
falciparum responsible for the majority of the disease burden and P. vivax being the …

TNF was originally described as a circulating factor that can cause necrosis of tumours, but
has since been identified as a key regulator of the inflammatory response. This review …

Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …

Tumor necrosis factor α (TNFα) is a potent immunomodulator and proinflammatory cytokine
that has been implicated in the pathogenesis of autoimmune and infectious diseases. For …

A large case-control study of malaria in West African children shows that a human leucocyte
class I antigen (HLA-Bw53) and an HLA class II haplotype (DRB1* 1302–DQB1* 0501) …

A further meeting, sponsored by WHO, was held on 4-8 December 1995 in Geneva. The
purpose was to review in great detail the latest scientific evidence for, and practical …

Quinoline-containing antimalarial drugs, such as chloroquine, quinine and mefloquine, are
mainstays of chemotherapy against malaria. The molecular basis of the action of these …

Experimenta naturae, like the glucose-6-phosphate dehydrogenase deficiency, indicate that
malaria parasites are highly susceptible to alterations in the redox equilibrium. This offers a …